Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hdeBPutative periplasmic transport protein; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins. Belongs to the HdeB family. (109 aa)    
Predicted Functional Partners:
STM2359
Similar to E. coli acid sensitivity protein, putative transporter (AAC74565.1); Blastp hit to AAC74565.1 (511 aa), 25% identity in aa 15 - 479.
   
  
 0.864
slp
Similar to E. coli putative outer membrane protein (AAC74876.1); Blastp hit to AAC74876.1 (193 aa), 90% identity in aa 1 - 193.
   
  
 0.791
asr
Acid shock protein; Required for growth and/or survival at acidic conditions.
   
  
 0.663
cbpA
Curved DNA-binding protein; DNA-binding protein that preferentially recognizes a curved DNA sequence. It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK. Its activity is inhibited by the binding of CbpM.
   
  
 0.511
mgtC
Mg2+ transport protein; Virulence factor required for growth in low Mg(2+) medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na(+)/K(+)-ATPase. Belongs to the MgtC/SapB family.
   
  
 0.500
STM1561
Putative outer membrane or secreted lipoprotein.
  
    0.498
osmC
Putative resistance protein; Osmotically inducible; similar to E. coli osmotically inducible protein (AAC74555.1); Blastp hit to AAC74555.1 (143 aa), 92% identity in aa 1 - 143.
  
  
 0.480
ybgS
Similar to E. coli putative homeobox protein (AAC73840.1); Blastp hit to AAC73840.1 (126 aa), 78% identity in aa 1 - 126.
   
  
 0.462
yjdE
Putative APC family putrescine/ornithine transport protein; Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
   
  
 0.449
uspA
Universal stress protein A; Required for resistance to DNA-damaging agents.
      
 0.443
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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