STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
steBPutative dipicolinate reductase; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. (133 aa)    
Predicted Functional Partners:
slrP
Leucine-rich repeat protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (thioredoxin). Leads to significant decrease of thioredoxin activity and increase of host cell death.
      
 0.717
sifB
Salmonella translocated effector: translocated by SPI-2; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues; Belongs to the Sif family.
   
  
 0.705
sopD2
Homologous to secreted protein sopD; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Contributes to the formation of Salmonella-induced filaments (Sifs) in infected epithelial cells and to replication in macrophages.
      
 0.677
steC
Putative inner membrane protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is a kinase, which is required for SPI-2 TTSS-dependent F-actin meshwork formation in infected host cells.
   
  
 0.629
pipB
Pathogenicity island encoded protein: SPI5; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Does not appear to be required for the formation or the maintenance of either Salmonella- containing vacuole (SCV) or the Salmonella-induced filaments (Sifs). Not required for intracellular replication in phagocytic cells.
   
  
 0.621
cigR
Putative inner membrane protein; Pathogenicity island encoded protein: SPI3; CigR (gi|4324614).
      
 0.611
sseJ
Salmonella translocated effector; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and negatively regulates the formation of Salmonella-induced filaments (Sifs) in epithelial cells. Has both deacylase and esterification activities in vitro, but esterification is probably the dominant activity in host cells. Significantly contributes to cholesterol esterification, which reduces cellular cholesterol in cells and abrogates the ability of SifA to associate with cholesterol and LAMP-1 v [...]
   
  
 0.591
sopE2
TypeIII-secreted protein effector: invasion-associated protein; Activator for CDC42 by directly engaging this Rho GTPase and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells. Also activates NF-kB, p38 and ERK kinases, which are known to be involved in the induction of IL-8 expression. Chaperone InvB is required for secretion, translocation and stabilization of intracellular levels of sopE2.
   
  
 0.584
sspH2
Leucine-rich repeat protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway.
      
 0.579
avrA
Putative inner membrane protein.
      
 0.578
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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