Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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co-expression
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gene co-occurrence
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tyrRTranscriptional regulatory protein TyrR; Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino acids (phenylalanine, tyrosine and tryptophan). These amino acids are suggested to act as co-effectors which bind to the TyrR protein to form an active regulatory protein. In most cases TyrR causes negative regulation, but positive effects on the tyrP gene have been observed at high phenylalani [...] (513 aa)    
Predicted Functional Partners:
tyrP
HAAAP family tyrosine-specific transport protein; Similar to E. coli tyrosine-specific transport system (AAC74977.1); Blastp hit to AAC74977.1 (403 aa), 88% identity in aa 1 - 403.
      
 0.896
aroF
3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP); Belongs to the class-I DAHP synthase family.
      
 0.895
ycjF
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC74404.1); Blastp hit to AAC74404.1 (353 aa), 88% identity in aa 1 - 353.
    
 0.894
ycjX
Similar to E. coli putative EC 2.1 enzymes (AAC74403.1); Blastp hit to AAC74403.1 (465 aa), 93% identity in aa 1 - 465.
  
  
 0.879
tyrA
Chorismate mutase T; Bifuctional; similar to E. coli chorismate mutase-T and prephenate dehydrogenase (AAC75649.1); Blastp hit to AAC75649.1 (373 aa), 95% identity in aa 1 - 372.
      
 0.874
tyrB
Tyrosine repressible; aromatic-amino-acid aminotransferase. (SW:TYRB_SALTY); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
     
 0.866
trpR
Transcriptional repressor for trp operon and aroH; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity).
      
 0.858
ycjG
Similar to E. coli putative muconate cycloisomerase I (AAC74407.1); Blastp hit to AAC74407.1 (335 aa), 85% identity in aa 15 - 335.
 
 
  
 0.809
rpoN
Sigma N factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of enzymes involved in arginine catabolism. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein GlnG(NtrC).
  
   
 0.781
aroP
APC family aromatic amino acid transporter; Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan); Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
      
 0.741
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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