Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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yciRPutative PAS/PAC domain protein; Diguanylate cyclase/phosphodiesterase domain 1; Diguanylate cyclase/phosphodiesterase domain 2; similar to E. coli orf, hypothetical protein (AAC74367.1); Blastp hit to AAC74367.1 (661 aa), 79% identity in aa 1 - 657. (660 aa)    
Predicted Functional Partners:
yhjH
Putative diguanylate cyclase/phosphodiesterase domain 3 containing protein; Similar to E. coli orf, hypothetical protein (AAC76550.1); Blastp hit to AAC76550.1 (256 aa), 79% identity in aa 2 - 256.
 
 
 0.984
yeaJ
Putative methyl-accepting chemotaxis protein; Diguanylate cyclase/phosphodiesterase domain 1; similar to E. coli orf, hypothetical protein (AAC74856.1); Blastp hit to AAC74856.1 (556 aa), 68% identity in aa 61 - 556.
 
 
 0.983
yegE
Putative PAS/PAC domain protein; Diguanylate cyclase/phosphodiesterase domain 1 and Diguanylate cyclase/phosphodiesterase domain 2 containing; similar to E. coli putative sensor-type protein (AAC75128.1); Blastp hit to AAC75128.1 (1105 aa), 76% identity in aa 540 - 437.
 
 
0.968
barA
Sensory histidine kinase; Similar to E. coli sensor-regulator, activates OmpR by phophorylation (AAC75828.1); Blastp hit to AAC75828.1 (918 aa), 90% identity in aa 1 - 918.
 
 0.942
arcB
Sensory histidine kinase in two-component regulatory system with ArcA; Senses redox conditions; similar to E. coli aerobic respiration sensor-response protein; histidine protein kinase/phosphatase, sensor for arcA (AAC76242.1); Blastp hit to AAC76242.1 (776 aa), 93% identity in aa 1 - 776.
 
 
 0.928
yehV
Putative transcriptional repressor (MerR family); Transcriptional activator of csgD, which is required for production of the curli (AgF).
  
 
 
 0.918
yhjO
Glycosyltransferase; Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase, when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae leads to a hydrophobic network with tightly packed cells embedded in a highly inert matrix.
  
  
 0.916
torS
Histidine kinase; Regulates tor operon; similar to E. coli sensor protein torS (regulator TorR) (AAC74078.1); Blastp hit to AAC74078.1 (904 aa), 62% identity in aa 1 - 896.
 
 0.900
STM3388
Putative membrane domain protein involved in signal transduction; Diguanylate cyclase/phosphodiesterase domain 1; Diguanylate cyclase/phosphodiesterase domain 2; similar to E. coli orf, hypothetical protein (AAC74367.1); Blastp hit to AAC74367.1 (661 aa), 37% identity in aa 228 - 652, 39% identity in aa 144 - 171.
 
 
0.896
csgD
Putative transcriptional regulator; Necessary for transcription of the csgAB operon. May have the capability to respond to starvation and/or high cell density by activating csgBA transcription (By similarity).
 
 
 0.894
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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