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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
adhESimilar to E. coli CoA-linked acetaldehyde dehydrogenase and iron-dependent alcohol dehydrogenase; pyruvate-formate-lyase deactivase (AAC74323.1); Blastp hit to AAC74323.1 (891 aa), 97% identity in aa 1 - 891; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (892 aa)    
Predicted Functional Partners:
pflB
Pyruvate formate lyase I, induced anaerobically; Similar to E. coli formate acetyltransferase 1 (AAC73989.1); Blastp hit to AAC73989.1 (760 aa), 96% identity in aa 1 - 760.
 
 
 0.993
pta
Phosphotransacetylase; Involved in acetate metabolism. Catalyzes the reversible interconversion of acetyl-CoA and acetyl phosphate. The direction of the overall reaction changes depending on growth conditions. Required for acetate recapture but not for acetate excretion when this organism is grown on ethanolamine; In the N-terminal section; belongs to the CobB/CobQ family.
  
 
 0.986
pflF
Similar to E. coli putative formate acetyltransferase (AAC73910.1); Blastp hit to AAC73910.1 (810 aa), 95% identity in aa 1 - 810.
  
 
 0.971
nifJ
Similar to E. coli putative oxidoreductase, Fe-S subunit (AAC74460.1); Blastp hit to AAC74460.1 (1174 aa), 92% identity in aa 1 - 1174.
  
 0.971
STM1627
Similar to E. coli alcohol dehydrogenase class III; formaldehyde dehydrogenase, glutathione-dependent (AAC73459.1); Blastp hit to AAC73459.1 (369 aa), 80% identity in aa 1 - 369; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
  
 0.970
aldB
Lactaldehyde dehydrogenase; similar to E. coli aldehyde dehydrogenase B (lactaldehyde dehydrogenase) (AAC76612.1); Blastp hit to AAC76612.1 (542 aa), 96% identity in aa 31 - 542.
  
 0.960
adhP
Alcohol dehydrogenase; Propanol preferring; similar to E. coli alcohol dehydrogenase (AAC74551.1); Blastp hit to AAC74551.1 (346 aa), 92% identity in aa 11 - 345.
  
 0.958
yjgB
Putative alcohol dehydrogenase; Similar to E. coli putative oxidoreductase (AAC77226.1); Blastp hit to AAC77226.1 (353 aa), 91% identity in aa 15 - 353.
  
 0.955
acs
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
  
 0.953
tdcE
Pyruvate formate-lyase 4; Similar to E. coli probable formate acetyltransferase 3 (AAC76149.1); Blastp hit to AAC76149.1 (746 aa), 93% identity in aa 1 - 741; 2-ketobutyrate formate-lyase.
 
 
 0.949
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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