STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sirCRegulator of invasion genes; Required for maximal expression of sirC, not required to invade host cells. (129 aa)    
Predicted Functional Partners:
ychA
Putative transcriptional regulator; Required for maximal expression of sirC, not required to invade host cells; Belongs to the UPF0162 family.
  
  
 0.991
hemK
Putative protoporphyrinogen oxidase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
  
    0.905
prfA
Peptide chain release factor RF-1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
    0.834
mobB
GTP-binding; similar to E. coli molybdopterin-guanine dinucleotide biosynthesis protein B (AAC76854.1); Blastp hit to AAC76854.1 (170 aa), 77% identity in aa 1 - 167.
      
 0.765
hemA
Glutamyl tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
    0.745
kdsA
3-deoxy-D-manno-octulosonic acid 8-P synthetase; Similar to E. coli 2-dehydro-3-deoxyphosphooctulonate aldolase (AAC74299.1); Blastp hit to AAC74299.1 (284 aa), 93% identity in aa 1 - 282; Belongs to the KdsA family.
  
    0.729
hemX
Similar to E. coli uroporphyrinogen III methylase (AAC76806.1); Blastp hit to AAC76806.1 (393 aa), 87% identity in aa 1 - 393.
  
  
  0.627
lolB
Outer membrane lipoprotein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
 
    0.603
cysG
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
   
 
  0.500
cbiK
Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis; Belongs to the CbiK family.
     
  0.499
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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