Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
cutCCopper homeostasis protein; Participates in the control of copper homeostasis. (248 aa)    
Predicted Functional Partners:
yecM
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74945.1); Blastp hit to AAC74945.1 (190 aa), 84% identity in aa 3 - 190.
 
  
 0.915
prpB
Putative carboxyphosphonoenolpyruvate mutase; Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2- methylisocitrate to yield pyruvate and succinate via an alpha-carboxy- carbanion intermediate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
   
  
 0.867
cutA
Putative periplasmic divalent cation tolerance protein; Involved in resistance toward heavy metals. Belongs to the CutA family.
      
 0.758
lpp
Murein lipoprotein; Plays an important role in virulence. A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non- covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane (By similarity).
      
 0.725
nagB
Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
 
   
 0.684
cpxP
Periplasmic repressor of cpx regulon by interaction with CpxA; Rescue from transitory stresses; similar to E. coli orf, hypothetical protein (AAC76896.1); Blastp hit to AAC76896.1 (122 aa), 94% identity in aa 1 - 122.
      
 0.673
nadE
NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
   0.648
nagE
Similar to E. coli PTS system, N-acetylglucosamine-specific enzyme IIABC (AAC73773.1); Blastp hit to AAC73773.1 (648 aa), 92% identity in aa 1 - 647.
 
   
 0.601
hpaD
4-hydroxyphenylacetate catabolism protein.
      
 0.579
metK
Methionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
    0.520
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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