STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tyrPHAAAP family tyrosine-specific transport protein; Similar to E. coli tyrosine-specific transport system (AAC74977.1); Blastp hit to AAC74977.1 (403 aa), 88% identity in aa 1 - 403. (403 aa)    
Predicted Functional Partners:
tyrR
Transcriptional regulatory protein TyrR; Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino acids (phenylalanine, tyrosine and tryptophan). These amino acids are suggested to act as co-effectors which bind to the TyrR protein to form an active regulatory protein. In most cases TyrR causes negative regulation, but positive effects on the tyrP gene have been observed at high phenylalani [...]
      
 0.895
aroP
APC family aromatic amino acid transporter; Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan); Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
      
 0.836
tyrB
Tyrosine repressible; aromatic-amino-acid aminotransferase. (SW:TYRB_SALTY); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
   
  
 0.830
trpR
Transcriptional repressor for trp operon and aroH; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity).
  
   
 0.702
yrbB
Putative STAS domain protein; Similar to E. coli orf, hypothetical protein (AAC76223.1); Blastp hit to AAC76223.1 (129 aa), 69% identity in aa 33 - 129.
      
 0.676
ycdZ
Putative inner membrane protein; Hypothetical protein in phoH-csgG intergenic region. (SW:YCDZ_SALTY).
  
    0.652
yrbC
Putative ABC superfamily transport protein; Atp&memb; similar to E. coli orf, hypothetical protein (AAC76224.1); Blastp hit to AAC76224.1 (211 aa), 93% identity in aa 1 - 211.
      
 0.580
yrbD
Putative ABC superfamily transport protein; Bind_prot; similar to E. coli orf, hypothetical protein (AAC76225.1); Blastp hit to AAC76225.1 (183 aa), 87% identity in aa 1 - 183.
      
 0.571
menC
o-succinylbenzoyl-CoA synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
  
     0.563
yecH
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74976.1); Blastp hit to AAC74976.1 (79 aa), 87% identity in aa 1 - 79.
       0.548
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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