Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
yecAPutative metal-binding protein; Similar to the C-terminal domain of SecA; similar to E. coli orf, hypothetical protein (AAC74978.1); Blastp hit to AAC74978.1 (221 aa), 81% identity in aa 1 - 221; Belongs to the UPF0149 family. (221 aa)    
Predicted Functional Partners:
STM1939
Putative glucose-6-phosphate dehydrogenase.
     
 0.890
secA
Preprotein translocase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
   
 
 0.684
pgsA
Phosphatidylglycerophosphate synthetase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
      
 0.677
dnaC
Chromosome replication protein; Initiation and chain elongation; similar to E. coli chromosome replication; initiation and chain elongation (AAC77317.1); Blastp hit to AAC77317.1 (245 aa), 93% identity in aa 1 - 245.
  
     0.650
yncE
Putative periplasmic protein; Similar to E. coli putative receptor (AAC74534.1); Blastp hit to AAC74534.1 (353 aa), 89% identity in aa 1 - 353.
  
     0.627
ychJ
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74315.1); Blastp hit to AAC74315.1 (152 aa), 78% identity in aa 1 - 152; Belongs to the UPF0225 family.
 
   
 0.592
STM1015
Gifsy-2 prophage ATPase involved in DNA replication initiation; dnaC protein homolog (gi|7443681).
  
     0.534
STM2625
Gifsy-1 prophage protein; Similar to dnaC homolog in S. typhimurium; dnaC protein homolog (gi|7443681).
  
     0.534
tsx
Nucleoside channel; Functions as substrate-specific channel for nucleosides and deoxynucleosides. Functions also in albicidin uptake and as receptor for colicin K; Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family.
  
    0.501
mdoB
Phosphoglycerol transferase I; Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones; Belongs to the OpgB family.
  
     0.485
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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