Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
yedPPutative hydrolase of the HAD superfamily; Similar to E. coli orf, hypothetical protein (AAC75021.1); Blastp hit to AAC75021.1 (271 aa), 75% identity in aa 1 - 269. (271 aa)    
Predicted Functional Partners:
yhaK
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76141.1); Blastp hit to AAC76141.1 (233 aa), 84% identity in aa 1 - 233; Belongs to the pirin family.
      
 0.897
STM3081
Similar to E. coli putative malate dehydrogenase (AAC73619.1); Blastp hit to AAC73619.1 (349 aa), 40% identity in aa 3 - 332; L-lactate dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family.
      
 0.896
accC
Acetyl CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
     
 0.865
cof
Putative hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P).
      
 0.858
ybhA
Putative hydrolase of the HAD superfamily; Similar to E. coli putative phosphatase (AAC73853.1); Blastp hit to AAC73853.1 (272 aa), 84% identity in aa 1 - 272.
      
 0.855
nrdF
Ribonucleoside-diphosphate reductase 2, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2F contains the tyrosyl radical required for catalysis.
      
 0.854
yidA
Putative hydrolase of the HAD superfamily; Similar to E. coli orf, hypothetical protein (AAC76720.1); Blastp hit to AAC76720.1 (270 aa), 93% identity in aa 1 - 270.
      
 0.851
mig-14
Putative transcription activator.
      
 0.767
iroC
Putative ATP binding cassette (ABC) transporter; Similar to E. coli ATP-binding transport protein; multicopy suppressor of htrB (AAC74000.1); Blastp hit to AAC74000.1 (582 aa), 26% identity in aa 14 - 582, 29% identity in aa 34 - 565.
      
 0.726
virK
virK-like protein; Similar to virK in Shigella; virulence gene; similar to E. coli putative enzyme (AAC73964.1); Blastp hit to AAC73964.1 (330 aa), 39% identity in aa 47 - 329.
      
 0.726
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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