STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dgcQPutative inner membrane protein; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Involved in the regulation of cellulose production (By similarity). (570 aa)    
Predicted Functional Partners:
yhjH
Putative diguanylate cyclase/phosphodiesterase domain 3 containing protein; Similar to E. coli orf, hypothetical protein (AAC76550.1); Blastp hit to AAC76550.1 (256 aa), 79% identity in aa 2 - 256.
  
  
 0.963
yhjK
Putative diguanylate cyclase/phosphodiesterase; Similar to E. coli orf, hypothetical protein (AAC76554.1); Blastp hit to AAC76554.1 (651 aa), 84% identity in aa 1 - 651.
 
  
 0.958
ylaB
Putative diguanylate cyclase/phosphodiesterase domain 2; Similar to E. coli orf, hypothetical protein (AAC73559.1); Blastp hit to AAC73559.1 (518 aa), 67% identity in aa 3 - 518.
 
  
 0.945
yjcC
Putative diguanylate cyclase/phosphodiesterase; Similar to E. coli orf, hypothetical protein (AAC77031.1); Blastp hit to AAC77031.1 (528 aa), 64% identity in aa 1 - 528.
 
   
 0.943
yfeA
Diguanylate cyclase/phosphodiesterase domain 2; similar to E. coli orf, hypothetical protein (AAC75454.1); Blastp hit to AAC75454.1 (768 aa), 68% identity in aa 45 - 766.
  
  
 0.933
yehV
Putative transcriptional repressor (MerR family); Transcriptional activator of csgD, which is required for production of the curli (AgF).
  
 
 
 0.917
csgD
Putative transcriptional regulator; Necessary for transcription of the csgAB operon. May have the capability to respond to starvation and/or high cell density by activating csgBA transcription (By similarity).
  
  
 0.914
yhjO
Glycosyltransferase; Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase, when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae leads to a hydrophobic network with tightly packed cells embedded in a highly inert matrix.
  
  
 0.913
STM2503
Putative diguanylate cyclase; Similar to E. coli putative cytochrome C-type biogenesis protein (AAC75556.1); Blastp hit to AAC75556.1 (747 aa), 73% identity in aa 1 - 733.
 
  
 0.906
rtn
Putative membrane protein involved in resistance to lambda and N4 phages; Similar to E. coli orf, hypothetical protein (AAC75237.1); Blastp hit to AAC75237.1 (518 aa), 70% identity in aa 1 - 518.
 
  
 0.859
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.