node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dam | dcm | STM3484 | STM1992 | DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | 0.668 |
dcm | dam | STM1992 | STM3484 | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | DNA adenine methylase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication; Belongs to the N(4)/N(6)-methyltransferase family. | 0.668 |
dcm | metK | STM1992 | STM3090 | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | Methionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.935 |
dcm | pfs | STM1992 | STM0207 | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulatio [...] | 0.902 |
dcm | ptr | STM1992 | STM2995 | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | Protease III; Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin. | 0.683 |
dcm | speD | STM1992 | STM0165 | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | S-adenosylmethionine decarboxylase, proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. | 0.900 |
dcm | ssb | STM1992 | STM4256 | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | ssDNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. | 0.744 |
dcm | vsr | STM1992 | STM1991 | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | DNA mismatch endonuclease; May nick specific sequences that contain T:G mispairs resulting from m5C-deamination. | 0.965 |
dcm | ybcI | STM1992 | STM0540 | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | Putative membrane-bound metal-dependent hydrolases; Similar to E. coli orf, hypothetical protein (AAC73629.1); Blastp hit to AAC73629.1 (173 aa), 86% identity in aa 1 - 169. | 0.468 |
dcm | ydhJ | STM1992 | STM1442 | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | Putative multidrug resistance efflux pump; Similar to E. coli putative membrane protein (AAC74716.1); Blastp hit to AAC74716.1 (299 aa), 83% identity in aa 9 - 299; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.581 |
dcm | yedJ | STM1992 | STM1993 | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | Putative hydrolase; Similar to E. coli orf, hypothetical protein (AAC75028.1); Blastp hit to AAC75028.1 (231 aa), 73% identity in aa 1 - 229. | 0.604 |
metK | dcm | STM3090 | STM1992 | Methionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | 0.935 |
metK | pfs | STM3090 | STM0207 | Methionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulatio [...] | 0.924 |
metK | speD | STM3090 | STM0165 | Methionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | S-adenosylmethionine decarboxylase, proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. | 0.963 |
pfs | dcm | STM0207 | STM1992 | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulatio [...] | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | 0.902 |
pfs | metK | STM0207 | STM3090 | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulatio [...] | Methionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.924 |
ptr | dcm | STM2995 | STM1992 | Protease III; Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin. | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | 0.683 |
speD | dcm | STM0165 | STM1992 | S-adenosylmethionine decarboxylase, proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | 0.900 |
speD | metK | STM0165 | STM3090 | S-adenosylmethionine decarboxylase, proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. | Methionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.963 |
ssb | dcm | STM4256 | STM1992 | ssDNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. | Similar to E. coli DNA cytosine methylase (AAC75027.1); Blastp hit to AAC75027.1 (472 aa), 83% identity in aa 1 - 472. | 0.744 |