Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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co-expression
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gene co-occurrence
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cbiESynthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the methylation of C-5 in cobalt-precorrin-7 to form cobalt-precorrin-8. (201 aa)    
Predicted Functional Partners:
cbiT
Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
 
 0.999
cbiD
Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
  
 0.999
cbiC
Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate; Belongs to the CobH/CbiC family.
 
 
 0.999
cbiG
Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the hydrolysis of the ring A acetate delta-lactone of cobalt-precorrin-5A resulting in the loss of the C-20 carbon and its attached methyl group in the form of acetaldehyde.
 
  
 0.998
cbiF
Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5A.
 
  
 0.998
cbiK
Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis; Belongs to the CbiK family.
 
  
 0.995
cbiH
Synthesis of vitamin B12 adenosyl cobalamide precursor; Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4.
 
  
 0.995
cbiJ
Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the reduction of the macrocycle of cobalt- precorrin-6A to cobalt-precorrin-6B.
 
  
 0.993
cibB
Synthesis of vitamin B12 adenosyl cobalamide precursor; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. However, the true cosubstrate could be (R)-1-amino-2-propanol O-2-phosphate, leading to cobinamide phosphate.
 
  
 0.993
cbiL
Synthesis of vitamin B12 adenosyl cobalamide precursor; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway.
 
  
 0.990
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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