STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
cbiASynthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Is able to use other nucleotide triphosphates as substrate, such as GTP or UTP, although less efficiently than ATP; Belongs to the CobB/CbiA family. (459 aa)    
Predicted Functional Partners:
cobT
Nicotinate-nucleotide dimethylbenzimidazole-P phophoribosyl transferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB) (Ref.7,. Able to use a variety of other nucleotide bases as substrate to create alternative lower ligands for cobamide. Belongs to the CobT family.
  
 0.999
cbiP
Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
  
 0.999
cbiC
Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate; Belongs to the CobH/CbiC family.
 
 0.999
cobD
Putative aminotransferase in cobalamin synthesis; Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.
  
 0.997
cbiD
Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
  
 0.997
cobS
Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
  
 0.996
cbiJ
Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the reduction of the macrocycle of cobalt- precorrin-6A to cobalt-precorrin-6B.
  
 0.996
cbiH
Synthesis of vitamin B12 adenosyl cobalamide precursor; Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4.
 
  
 0.996
cbiF
Synthesis of vitamin B12 adenosyl cobalamide precursor; Catalyzes the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5A.
  
 0.996
cobU
Cobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. Belongs to the CobU/CobP family.
 
  
 0.995
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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