close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rfbUMannosyl transferase; LPS side chain defect; RFBU protein. (SW:RFBU_SALTY). (353 aa)    
Predicted Functional Partners:
rfbP
Undecaprenol-phosphate galactosephosphotransferase, and; Is responsible for transferring galactose-1-phosphate to the lipid precursor undecaprenol phosphate in the first steps of O- polysaccharide biosynthesis; Belongs to the bacterial sugar transferase family.
 
  
 0.988
rfbM
Mannose-1-phosphate guanylyltransferase; Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group B O antigen; Belongs to the mannose-6-phosphate isomerase type 2 family.
 
  
 0.982
rfbN
LPS side chain defect: putative rhamnosyltransferase RFBN. (SW:RFBN_SALTY).
  
  
 0.961
rfbK
Phosphomannomutase; Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group B O antigen; Belongs to the phosphohexose mutase family.
  
  
 0.940
rfbV
Abequosyltransferase; Catalyzes the transfer of CDP-abequose on D-mannosyl-L- rhamnosyl-D-galactose-1-diphospholipid to yield D-abequosyl-D-mannosyl- rhamnosyl-D-galactose-1-diphospholipid.
  
  
 0.901
rfbX
Putative O-antigen transferase; May be involved in the translocation process of the nascent O-polysaccharide molecules and/or its ligation to lipid A core units.
  
  
 0.895
rfaK
Putative hexose transferase; Adds the terminal N-acetyl-D-glucosamine group on the glucose(II) group of LPS; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
  
  
 0.882
rfbA
dTDP-glucose pyrophosphorylase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Is also able to convert non natural substrates such as a wide array of alpha-D- hexopyranosyl, deoxy-alpha-D-glucopyranosyl, aminodeoxy-alpha-D- hexopyranosyl and acetamidodeoxy-alpha-D-hexopyranosyl phosphates to their corresponding dTDP- and UDP-nucleotide sugars.
  
  
 0.844
rfbH
CDP-6deoxy-D-xylo-4-hexulose-3-dehydrase; LPS side chain defect; lipopolysaccharide biosynthesis protein RFBH. (SW:RFBH_SALTY); Belongs to the DegT/DnrJ/EryC1 family.
  
  
 0.824
rfbF
Glucose-1-phosphate cytidylyltransferase; Involved in the biosynthesis of the tyvelose, a 3,6- dideoxyhexose found in the O-antigen of the surface lipopolysaccharides. It catalyzes the transfer of a CMP moiety from CTP to glucose 1-phosphate (By similarity).
  
 
 0.764
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.