Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
wcaIPutative glycosyl transferase; In colanic acid gene cluster; similar to E. coli putative colanic biosynthesis glycosyl transferase (AAC75111.1); Blastp hit to AAC75111.1 (407 aa), 85% identity in aa 1 - 407. (407 aa)    
Predicted Functional Partners:
wcaF
Putative acyltransferase; In colanic acid gene cluster; similar to E. coli putative transferase (AAC75115.1); Blastp hit to AAC75115.1 (182 aa), 87% identity in aa 1 - 180.
 
  
 0.994
wcaC
Putative glycosyl transferase; In colanic acid gene cluster; similar to E. coli putative glycosyl transferase (AAC75118.1); Blastp hit to AAC75118.1 (405 aa), 80% identity in aa 1 - 405.
 
  
 0.985
gmd
GDP-D-mannose dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.
 
  
 0.979
wcaG
Bifunctional GDP fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
 
  
 0.975
wcaE
Putative transferase; In colanic acid gene cluster; similar to E. coli putative colanic acid biosynthesis glycosyl transferase (AAC75116.1); Blastp hit to AAC75116.1 (248 aa), 71% identity in aa 1 - 248.
 
  
 0.920
manC
Mannose-1-phosphate; Involved in the biosynthesis of the capsular polysaccharide colanic acid.
  
  
 0.884
wzc
Putative tyrosine-protein kinase; Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium (By similarity). Belongs to the etk/wzc family.
 
  
 0.875
wcaB
Putative acyl transferase; In colanic acid gene cluster; similar to E. coli putative transferase (AAC75119.1); Blastp hit to AAC75119.1 (162 aa), 91% identity in aa 1 - 160; Belongs to the transferase hexapeptide repeat family.
  
  
 0.860
wcaA
Putative glycosyl transferase; In colanic acid gene cluster; similar to E. coli putative regulator (AAC75120.1); Blastp hit to AAC75120.1 (279 aa), 91% identity in aa 3 - 279.
 
  
 0.842
wecC
UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily.
 
  
 0.830
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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