Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
wcaHGDP-mannose mannosyl hydrolase; In colanic acid gene clustersimilar to E. coli GDP-mannose mannosyl hydrolase (AAC75112.1); Blastp hit to AAC75112.1 (160 aa), 78% identity in aa 15 - 149. (99 aa)    
Predicted Functional Partners:
wcaG
Bifunctional GDP fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
  
    0.820
wcaB
Putative acyl transferase; In colanic acid gene cluster; similar to E. coli putative transferase (AAC75119.1); Blastp hit to AAC75119.1 (162 aa), 91% identity in aa 1 - 160; Belongs to the transferase hexapeptide repeat family.
  
    0.816
gmd
GDP-D-mannose dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.
  
    0.799
wcaC
Putative glycosyl transferase; In colanic acid gene cluster; similar to E. coli putative glycosyl transferase (AAC75118.1); Blastp hit to AAC75118.1 (405 aa), 80% identity in aa 1 - 405.
  
    0.786
manC
Mannose-1-phosphate; Involved in the biosynthesis of the capsular polysaccharide colanic acid.
  
  
 0.785
wcaA
Putative glycosyl transferase; In colanic acid gene cluster; similar to E. coli putative regulator (AAC75120.1); Blastp hit to AAC75120.1 (279 aa), 91% identity in aa 3 - 279.
  
    0.784
wcaF
Putative acyltransferase; In colanic acid gene cluster; similar to E. coli putative transferase (AAC75115.1); Blastp hit to AAC75115.1 (182 aa), 87% identity in aa 1 - 180.
  
    0.771
wcaE
Putative transferase; In colanic acid gene cluster; similar to E. coli putative colanic acid biosynthesis glycosyl transferase (AAC75116.1); Blastp hit to AAC75116.1 (248 aa), 71% identity in aa 1 - 248.
  
    0.771
rfc
O-antigen polymerase; May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS.
      
 0.769
wcaD
Similar to E. coli putative colanic acid polymerase (AAC75117.1); Blastp hit to AAC75117.1 (405 aa), 93% identity in aa 1 - 404.
  
    0.766
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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