Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
yegSPutative diacylglycerol kinase catalytic domain containing protein; In vitro does not phosphorylate diacylglycerol, sphingosine, N,N-dimethylsphingosine; threo-dihydrosphingosine, erythro- dihydrosphingosine, C2 ceramide, C6 ceramide, phosphatidylinositol or dimethylsphingosine. The potential in vivo substrate is unknown. (299 aa)    
Predicted Functional Partners:
yjfL
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC77141.1); Blastp hit to AAC77141.1 (132 aa), 90% identity in aa 1 - 132.
      
 0.896
yegQ
Putative protease; Similar to E. coli orf, hypothetical protein (AAC75142.1); Blastp hit to AAC75142.1 (453 aa), 96% identity in aa 1 - 453.
     
 0.778
dgkA
Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid.
      
 0.738
STM2314
Putative chemotaxis signal transduction protein; Similar to E. coli positive regulator of CheA protein activity (AAC74957.1); Blastp hit to AAC74957.1 (167 aa), 25% identity in aa 18 - 151.
      0.665
mopA
Chaperone Hsp60 with peptide-dependent ATPase activity; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
    
  0.565
yeiU
Putative permease; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family.
  
     0.473
yfdC
Similar to E. coli putative transport (AAC75407.1); Blastp hit to AAC75407.1 (310 aa), 87% identity in aa 1 - 304.
  
  
 0.465
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate.
      
 0.437
gltB
Similar to E. coli glutamate synthase, large subunit (AAC76244.1); Blastp hit to AAC76244.1 (1517 aa), 95% identity in aa 32 - 1517.
  
  
 0.418
ygaM
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC75719.1); Blastp hit to AAC75719.1 (113 aa), 86% identity in aa 1 - 112.
  
    0.416
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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