STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STM2197Similar to E. coli 3-phosphoserine phosphatase (AAC77341.1); Blastp hit to AAC77341.1 (322 aa), 39% identity in aa 111 - 305. (295 aa)    
Predicted Functional Partners:
hisI
phosphoribosyl-AMP cyclohydrolase; Bifunctional; histidine biosynthesis bifunctional protein HISIE [includes:phosphoribosyl-amp cyclohydrolase ]. (SW:HIS2_SALTY); phosphoribosyl-ATP pyrophosphatase; In the C-terminal section; belongs to the PRA-PH family.
  
  
 0.942
hisB
Imidazole glycerol-phosphate dehydratase; Bifunctional; histidine biosynthesis bifunctional protein HISB [includes:histidinol-phosphatase ]. (SW:HIS7_SALTY); In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
  
  
 0.726
serC
3-phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 
 0.692
STM2198
Putative regulatory protein; Similar to E. coli regulator of uhpT (AAC76690.1); Blastp hit to AAC76690.1 (440 aa), 39% identity in aa 5 - 428.
  
    0.686
hisF
Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
  
  
 0.682
hisA
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotideisomerase. (SW:HIS4_SALTY).
  
  
 0.628
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).
  
 0.609
hisH
Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
  
  
 0.582
cysE
Serine acetyltransferase. (SW:CYSE_SALTY); Belongs to the transferase hexapeptide repeat family.
  
 
 0.550
STM2196
Putative D-serine dehydratase; Similar to E. coli L-serine deaminase (AAC74884.1); Blastp hit to AAC74884.1 (454 aa), 48% identity in aa 1 - 452; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
  
 0.526
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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