STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lysPSimilar to E. coli lysine-specific permease (AAC75217.1); Blastp hit to AAC75217.1 (489 aa), 94% identity in aa 1 - 489. (489 aa)    
Predicted Functional Partners:
cadC
OmpR family; similar to E. coli transcriptional activator of cad operon (AAC77094.1); Blastp hit to AAC77094.1 (512 aa), 58% identity in aa 1 - 512.
    
 
 0.928
clpX
Specificity component of clpA-clpP ATP-dependent serine protease, chaperone; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
     
 0.904
aspC
Similar to E. coli aspartate aminotransferase (AAC74014.1); Blastp hit to AAC74014.1 (396 aa), 95% identity in aa 1 - 396; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
   
  
 0.902
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
   
  
 0.898
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
   
  
 0.893
STM4538
Putative PTS permease; Similar to E. coli PTS enzyme IID, mannose-specific (AAC74889.1); Blastp hit to AAC74889.1 (286 aa), 41% identity in aa 6 - 283.
      
 0.893
fadD
acyl-CoA synthetase; Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids; Belongs to the ATP-dependent AMP-binding enzyme family.
   
  
 0.819
icdA
Isocitrate dehydrogenase in e14 prophage; Specific for NADP+; similar to E. coli isocitrate dehydrogenase, specific for NADP+ (AAC74220.1); Blastp hit to AAC74220.1 (416 aa), 96% identity in aa 1 - 416.
   
  
 0.750
yeiE
Similar to E. coli putative transcriptional regulator LYSR-type (AAC75218.1); Blastp hit to AAC75218.1 (293 aa), 91% identity in aa 1 - 287; Belongs to the LysR transcriptional regulatory family.
     
 0.670
cadB
APC family lysine/cadaverine transport protein; Similar to E. coli transport of lysine/cadaverine (AAC77093.1); Blastp hit to AAC77093.1 (444 aa), 90% identity in aa 1 - 440.
  
   
 0.587
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.