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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STM2230Putative peptidase; Similar to E. coli SOS mutagenesis; error-prone repair; processed to UmuD'; forms complex with UmuC (AAC74267.1); Blastp hit to AAC74267.1 (139 aa), 38% identity in aa 22 - 139; Belongs to the peptidase S24 family. (167 aa)    
Predicted Functional Partners:
umuC
Error-prone repair protein; Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template.
 
 
 0.975
recA
DNA strand exchange and recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
  
 
 0.896
dinP
DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
 
 0.783
hsdM
DNA methylase M, host modification; Methylation of specific adenine residues; required for both restriction and modification activities (By similarity). The StySJI enzyme recognizes 5'-GAGN(6)GTRC-3'; Belongs to the N(4)/N(6)-methyltransferase family.
  
  
 0.717
STM2231
ssrB-regulated factor; Similar to msgA; virulence protein msga (SW:MSGA_SALTY).
  
    0.711
STM2233
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75413.1); Blastp hit to AAC75413.1 (146 aa), 46% identity in aa 5 - 146.
   
    0.594
oafA
Acetylation of the O-antigen (LPS); O-antigen five:.
  
  
 0.589
recN
Protein used in recombination and DNA repair; May be involved in recombinational repair of damaged DNA.
   
  
 0.568
STM4492
Putative cytoplasmic protein.
  
    0.544
yebG
DNA damage-inducible gene in SOS regulon, dependent on cyclic AMP and H-NS; Similar to E. coli orf, hypothetical protein (AAC74918.1); Blastp hit to AAC74918.1 (96 aa), 79% identity in aa 1 - 96.
   
  
 0.538
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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