Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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apbEPutative thiamine biosynthesis lipoprotein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein such as NqrB and NqrC, two subunits of the NQR complex; Belongs to the ApbE family. (350 aa)    
Predicted Functional Partners:
mrp
Putative ATP-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP. Both activities are required for function in vivo, but the ability to hydrolyze ATP is not necessary for Fe-S cluster transfer.
      
 0.897
ydgO
Putative oxidoreductase; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR; Belongs to the NqrB/RnfD family.
 
  
 0.889
rseC
Similar to E. coli sigma-E factor, negative regulatory protein (AAC75623.1); Blastp hit to AAC75623.1 (159 aa), 81% identity in aa 1 - 159.
  
  
 0.885
rsxA
Putative inner membrane oxidoreductase protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.
 
  
 0.843
ydgQ
Putative membrane NADH-quinone reductase protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.
 
  
 0.839
ydgP
Putative Na+-transporting NADH:ubiquinone oxidoreductase gamma subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR; Belongs to the RnfG family.
 
  
 0.817
thiH
Thiamin biosynthesis protein, thiazole moiety; Catalyzes the radical-mediated cleavage of tyrosine to 2- iminoacetate and 4-cresol; Belongs to the radical SAM superfamily. ThiH family.
      
 0.767
gshA
Glutamate--cysteine ligase. (SW:GSH1_SALTY); Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
   
  
 0.729
yeeO
Putative MATE family transport protein; Similar to E. coli orf, hypothetical protein (AAC75048.1); Blastp hit to AAC75048.1 (547 aa), 82% identity in aa 53 - 533.
      
 0.722
yggX
Putative cytoplasmic protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. Necessary to maintain high levels of aconitase under oxidative stress.
      
 0.718
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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