STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
Coexpression
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[Homology]
Score
yfaWPutative galactonate dehydratase; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). Can also dehydrate L-lyxonate and L-mannonate, although less efficiently, but not 2-keto-4-hydroxyheptane-1,7-dioate. Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily. (405 aa)    
Predicted Functional Partners:
yfaV
Similar to E. coli putative transport protein (AAC75306.1); Blastp hit to AAC75306.1 (442 aa), 91% identity in aa 14 - 442.
 
  
 0.990
rhmA
Putative 2,4-dihydoxyhept-2-ene-1,7-dioic acid aldolase; Catalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily.
 
 
 0.979
yfaX
Similar to E. coli putative regulator (AAC75308.1); Blastp hit to AAC75308.1 (260 aa), 87% identity in aa 1 - 260.
 
  
 0.966
yiiL
Putative cytoplasmic protein; Involved in the anomeric conversion of L-rhamnose.
     
 0.909
hpaI
4-hydroxyphenylacetate catabolism protein; Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2- ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
  
  
 0.846
yifE
Putative LysR type transcriptional regulator with pssR; Similar to E. coli orf, hypothetical protein (AAC77485.1); Blastp hit to AAC77485.1 (112 aa), 95% identity in aa 1 - 112; Belongs to the UPF0438 family.
      
 0.692
STM3697
Putative mandelate racemase; Catalyzes the efficient dehydration of both L-talarate and galactarate to 5-keto-4-deoxy-D-glucarate. Also catalyzes the epimerization of L-talarate to galactarate; epimerization occurs in competition with dehydration. Is required for the utilization of L- talarate as a carbon source. Also functions in galactarate utilization. Is not active on other acid sugars; Belongs to the mandelate racemase/muconate lactonizing enzyme family.
 
  
0.624
STM2288
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75309.1); Blastp hit to AAC75309.1 (400 aa), 83% identity in aa 342 - 397.
       0.611
STM4044
Putative iron-containing alcohol dehydrogenase; Similar to E. coli putative oxidoreductase (AAC76613.1); Blastp hit to AAC76613.1 (382 aa), 47% identity in aa 8 - 379.
     
 0.513
rhaA
L-rhamnose isomerase. (SW:RHAA_SALTY).
      
 0.478
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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