| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ais | arnD | STM2296 | STM2300 | Aluminum inducible protein; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. Required for iron(3+) resistance. Belongs to the phosphoglycerate mutase family. Ais subfamily. | Putative cytoplasmic protein; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (Probable). | 0.725 |
| ais | basR | STM2296 | STM4292 | Aluminum inducible protein; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. Required for iron(3+) resistance. Belongs to the phosphoglycerate mutase family. Ais subfamily. | Response regulator in two-component regulatory system with BasS; Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin. Represses the transcription of pmrD. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well. | 0.762 |
| ais | pagO | STM2296 | STM1862 | Aluminum inducible protein; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. Required for iron(3+) resistance. Belongs to the phosphoglycerate mutase family. Ais subfamily. | Predicted integral membrane protein; PAGO protein. (SW:PAGO_SALTY). | 0.671 |
| ais | pmrD | STM2296 | STM2304 | Aluminum inducible protein; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. Required for iron(3+) resistance. Belongs to the phosphoglycerate mutase family. Ais subfamily. | Polymyxin resistance protein B; Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance; Belongs to the PmrD family. | 0.774 |
| ais | udg | STM2296 | STM2080 | Aluminum inducible protein; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. Required for iron(3+) resistance. Belongs to the phosphoglycerate mutase family. Ais subfamily. | UDP-glucose 6-dehydrogenase. (SW:UDG_SALTY). | 0.730 |
| ais | ybjG | STM2296 | STM0865 | Aluminum inducible protein; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. Required for iron(3+) resistance. Belongs to the phosphoglycerate mutase family. Ais subfamily. | Putative permease; Similar to E. coli orf, hypothetical protein (AAC73928.1); Blastp hit to AAC73928.1 (198 aa), 78% identity in aa 1 - 198. | 0.741 |
| ais | yfbE | STM2296 | STM2297 | Aluminum inducible protein; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. Required for iron(3+) resistance. Belongs to the phosphoglycerate mutase family. Ais subfamily. | Putative DegT/DnrJ/EryC1/StrS family; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity); Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. | 0.886 |
| ais | yibD | STM2296 | STM3707 | Aluminum inducible protein; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. Required for iron(3+) resistance. Belongs to the phosphoglycerate mutase family. Ais subfamily. | Similar to E. coli putative regulator (AAC76639.1); Blastp hit to AAC76639.1 (344 aa), 80% identity in aa 1 - 343. | 0.698 |
| ais | yijP | STM2296 | STM4118 | Aluminum inducible protein; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. Required for iron(3+) resistance. Belongs to the phosphoglycerate mutase family. Ais subfamily. | Putative integral membrane protein; Catalyzes the addition of a phosphoethanolamine moiety to the outer membrane lipopolysaccharide core; Belongs to the phosphoethanolamine transferase family. EptC/CptA subfamily. | 0.838 |
| ais | yjdB | STM2296 | STM4293 | Aluminum inducible protein; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. Required for iron(3+) resistance. Belongs to the phosphoglycerate mutase family. Ais subfamily. | Putative integral membrane protein; Catalyzes the addition of a phosphoethanolamine moiety to the lipid A. The phosphoethanolamine modification is required for resistance to polymyxin; Belongs to the phosphoethanolamine transferase family. EptA subfamily. | 0.832 |
| arnD | ais | STM2300 | STM2296 | Putative cytoplasmic protein; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (Probable). | Aluminum inducible protein; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. Required for iron(3+) resistance. Belongs to the phosphoglycerate mutase family. Ais subfamily. | 0.725 |
| arnD | udg | STM2300 | STM2080 | Putative cytoplasmic protein; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (Probable). | UDP-glucose 6-dehydrogenase. (SW:UDG_SALTY). | 0.493 |
| arnD | ybjG | STM2300 | STM0865 | Putative cytoplasmic protein; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (Probable). | Putative permease; Similar to E. coli orf, hypothetical protein (AAC73928.1); Blastp hit to AAC73928.1 (198 aa), 78% identity in aa 1 - 198. | 0.460 |
| arnD | yfbE | STM2300 | STM2297 | Putative cytoplasmic protein; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (Probable). | Putative DegT/DnrJ/EryC1/StrS family; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity); Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. | 0.981 |
| basR | ais | STM4292 | STM2296 | Response regulator in two-component regulatory system with BasS; Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin. Represses the transcription of pmrD. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well. | Aluminum inducible protein; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. Required for iron(3+) resistance. Belongs to the phosphoglycerate mutase family. Ais subfamily. | 0.762 |
| basR | pmrD | STM4292 | STM2304 | Response regulator in two-component regulatory system with BasS; Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin. Represses the transcription of pmrD. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well. | Polymyxin resistance protein B; Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance; Belongs to the PmrD family. | 0.999 |
| basR | udg | STM4292 | STM2080 | Response regulator in two-component regulatory system with BasS; Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin. Represses the transcription of pmrD. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well. | UDP-glucose 6-dehydrogenase. (SW:UDG_SALTY). | 0.899 |
| basR | ybjG | STM4292 | STM0865 | Response regulator in two-component regulatory system with BasS; Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin. Represses the transcription of pmrD. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well. | Putative permease; Similar to E. coli orf, hypothetical protein (AAC73928.1); Blastp hit to AAC73928.1 (198 aa), 78% identity in aa 1 - 198. | 0.450 |
| basR | yfbE | STM4292 | STM2297 | Response regulator in two-component regulatory system with BasS; Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin. Represses the transcription of pmrD. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well. | Putative DegT/DnrJ/EryC1/StrS family; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity); Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. | 0.939 |
| basR | yibD | STM4292 | STM3707 | Response regulator in two-component regulatory system with BasS; Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin. Represses the transcription of pmrD. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virulence as well. | Similar to E. coli putative regulator (AAC76639.1); Blastp hit to AAC76639.1 (344 aa), 80% identity in aa 1 - 343. | 0.674 |