| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ackA | hfq | STM2337 | STM4361 | Acetate kinase A; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Has broad substrate specificity and can also utilize GTP, UTP and CTP. Can also phosphorylate propionate, but has very low activity with formate and is inactive with butyrate; Belongs to the acetokinase family. | Host factor I for bacteriophage Q beta replication; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity). Plays a central regulatory role in the microbial response to space flight conditions. Is essential for virulence and is required for efficient invasion of non-phagocytic cells. | 0.425 |
| ackA | ptsH | STM2337 | STM2431 | Acetate kinase A; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Has broad substrate specificity and can also utilize GTP, UTP and CTP. Can also phosphorylate propionate, but has very low activity with formate and is inactive with butyrate; Belongs to the acetokinase family. | Phosphohistidinoprotein-hexose phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. | 0.468 |
| ackA | yfbU | STM2337 | STM2335 | Acetate kinase A; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Has broad substrate specificity and can also utilize GTP, UTP and CTP. Can also phosphorylate propionate, but has very low activity with formate and is inactive with butyrate; Belongs to the acetokinase family. | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75354.1); Blastp hit to AAC75354.1 (170 aa), 95% identity in aa 7 - 170; Belongs to the UPF0304 family. | 0.437 |
| ackA | yfbV | STM2337 | STM2336 | Acetate kinase A; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Has broad substrate specificity and can also utilize GTP, UTP and CTP. Can also phosphorylate propionate, but has very low activity with formate and is inactive with butyrate; Belongs to the acetokinase family. | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75355.1); Blastp hit to AAC75355.1 (151 aa), 95% identity in aa 1 - 151. | 0.768 |
| hfq | ackA | STM4361 | STM2337 | Host factor I for bacteriophage Q beta replication; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity). Plays a central regulatory role in the microbial response to space flight conditions. Is essential for virulence and is required for efficient invasion of non-phagocytic cells. | Acetate kinase A; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Has broad substrate specificity and can also utilize GTP, UTP and CTP. Can also phosphorylate propionate, but has very low activity with formate and is inactive with butyrate; Belongs to the acetokinase family. | 0.425 |
| hfq | pal | STM4361 | STM0749 | Host factor I for bacteriophage Q beta replication; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity). Plays a central regulatory role in the microbial response to space flight conditions. Is essential for virulence and is required for efficient invasion of non-phagocytic cells. | Tol protein required for outer membrane integrity; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. | 0.760 |
| hfq | ptsH | STM4361 | STM2431 | Host factor I for bacteriophage Q beta replication; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity). Plays a central regulatory role in the microbial response to space flight conditions. Is essential for virulence and is required for efficient invasion of non-phagocytic cells. | Phosphohistidinoprotein-hexose phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. | 0.946 |
| hfq | yfbU | STM4361 | STM2335 | Host factor I for bacteriophage Q beta replication; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity). Plays a central regulatory role in the microbial response to space flight conditions. Is essential for virulence and is required for efficient invasion of non-phagocytic cells. | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75354.1); Blastp hit to AAC75354.1 (170 aa), 95% identity in aa 7 - 170; Belongs to the UPF0304 family. | 0.421 |
| pal | hfq | STM0749 | STM4361 | Tol protein required for outer membrane integrity; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. | Host factor I for bacteriophage Q beta replication; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity). Plays a central regulatory role in the microbial response to space flight conditions. Is essential for virulence and is required for efficient invasion of non-phagocytic cells. | 0.760 |
| pal | ptsH | STM0749 | STM2431 | Tol protein required for outer membrane integrity; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. | Phosphohistidinoprotein-hexose phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. | 0.914 |
| pal | yfbU | STM0749 | STM2335 | Tol protein required for outer membrane integrity; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75354.1); Blastp hit to AAC75354.1 (170 aa), 95% identity in aa 7 - 170; Belongs to the UPF0304 family. | 0.419 |
| ptsH | ackA | STM2431 | STM2337 | Phosphohistidinoprotein-hexose phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. | Acetate kinase A; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Has broad substrate specificity and can also utilize GTP, UTP and CTP. Can also phosphorylate propionate, but has very low activity with formate and is inactive with butyrate; Belongs to the acetokinase family. | 0.468 |
| ptsH | hfq | STM2431 | STM4361 | Phosphohistidinoprotein-hexose phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. | Host factor I for bacteriophage Q beta replication; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity). Plays a central regulatory role in the microbial response to space flight conditions. Is essential for virulence and is required for efficient invasion of non-phagocytic cells. | 0.946 |
| ptsH | pal | STM2431 | STM0749 | Phosphohistidinoprotein-hexose phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. | Tol protein required for outer membrane integrity; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. | 0.914 |
| ptsH | yfbU | STM2431 | STM2335 | Phosphohistidinoprotein-hexose phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75354.1); Blastp hit to AAC75354.1 (170 aa), 95% identity in aa 7 - 170; Belongs to the UPF0304 family. | 0.500 |
| slyD | yfbU | STM3455 | STM2335 | Similar to E. coli FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) (AAC76374.1); Blastp hit to AAC76374.1 (196 aa), 97% identity in aa 1 - 196. | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75354.1); Blastp hit to AAC75354.1 (170 aa), 95% identity in aa 7 - 170; Belongs to the UPF0304 family. | 0.551 |
| yeaA | yfbU | STM1291 | STM2335 | Hypothetical protein; Putative domain frequently associated with peptide methionine sulfoxide reductase; similar to E. coli orf, hypothetical protein (AAC74848.1); Blastp hit to AAC74848.1 (137 aa), 85% identity in aa 1 - 137. | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75354.1); Blastp hit to AAC75354.1 (170 aa), 95% identity in aa 7 - 170; Belongs to the UPF0304 family. | 0.469 |
| yfbS | yfbT | STM2333 | STM2334 | Putative response regulator; Similar to E. coli putative transport protein (AAC75352.1); Blastp hit to AAC75352.1 (610 aa), 90% identity in aa 1 - 610. | Similar to E. coli putative phosphatase (AAC75353.1); Blastp hit to AAC75353.1 (222 aa), 86% identity in aa 1 - 221. | 0.806 |
| yfbS | yfbU | STM2333 | STM2335 | Putative response regulator; Similar to E. coli putative transport protein (AAC75352.1); Blastp hit to AAC75352.1 (610 aa), 90% identity in aa 1 - 610. | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75354.1); Blastp hit to AAC75354.1 (170 aa), 95% identity in aa 7 - 170; Belongs to the UPF0304 family. | 0.851 |
| yfbS | yfbV | STM2333 | STM2336 | Putative response regulator; Similar to E. coli putative transport protein (AAC75352.1); Blastp hit to AAC75352.1 (610 aa), 90% identity in aa 1 - 610. | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75355.1); Blastp hit to AAC75355.1 (151 aa), 95% identity in aa 1 - 151. | 0.464 |
