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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yfcDPutative NTP pyrophosphohydrolase; Similar to E. coli putative regulator (AAC75359.1); Blastp hit to AAC75359.1 (180 aa), 92% identity in aa 1 - 180. (184 aa)    
Predicted Functional Partners:
yfcE
Putative phosphoesterase; Similar to E. coli orf, hypothetical protein (AAC75360.1); Blastp hit to AAC75360.1 (184 aa), 85% identity in aa 2 - 183.
 
    0.901
yhhK
Putative acetyltransferase; Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion (By similarity). Binding of CoA or a derivative to PanM leads to interaction with PanD, which promotes the processing and activation of pro-PanD, and subsequent substrate- mediated inhibition of the active form of PanD (By similarity). Lacks acetyltransferase activity.
      
 0.897
panC
Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
   
 
 0.869
panD
Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine; Belongs to the PanD family.
      
 0.809
STM2573
Putative ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
      
 0.768
yfcF
Putative glutathione-S-transferase; Similar to E. coli orf, hypothetical protein (AAC75361.1); Blastp hit to AAC75361.1 (214 aa), 80% identity in aa 1 - 214.
  
    0.553
yhjD
Putative tRNA-processing ribonuclease; Similar to E. coli orf, hypothetical protein (AAC76547.1); Blastp hit to AAC76547.1 (337 aa), 85% identity in aa 1 - 336.
  
     0.518
ypfI
Putative acetyltransferase; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
  
    0.481
yfhK
Putative sensory kinase in regulatory system; Similar to E. coli putative 2-component sensor protein (AAC75609.1); Blastp hit to AAC75609.1 (496 aa), 87% identity in aa 19 - 496.
  
 
   0.468
apbA
Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. Has a strong preference for NADPH over NADH as the electron acceptor. Pantoate, ketoisovalerate, oxaloacetate, pyruvate, 3-hydroxypyruvate, alpha-ketoglutarate, alpha-ketobutyrate, and acetaldehyde cannot serve as substrates for reduction.
      
 0.457
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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