Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hisPHistidine and lysine/arginine/ornithine transport protein; Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Responsible for energy coupling to the transport system. (258 aa)    
Predicted Functional Partners:
hisM
Histidine and lysine/arginine/ornithine transport protein; Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP.
 
 0.999
hisQ
Histidine and lysine/arginine/ornithine transport system; Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP.
 
 0.999
hisJ
Histidine transport protein; Part of the histidine permease ABC transporter. Binds histidine. Interacts with HisQMP and stimulates ATPase activity of HisP, which results in histidine translocation. May have some additional function(s) in translocation that is independent of the stimulation of ATP hydrolysis.
 
 
 0.999
argT
Lysine/arginine/ornithine transport protein; Part of an ABC transporter involved in lysine, arginine and ornithine transport. Stimulates ATPase activity of HisP.
 
 
 0.996
yecS
Putative ABC-type amino acid transporter; Permease component; similar to E. coli putative transport system permease protein (former yecC) (AAC74985.1); Blastp hit to AAC74985.1 (222 aa), 93% identity in aa 1 - 222.
    0.973
artQ
Arginine 3rd transport system; ABC superfamily (membrane); similar to E. coli arginine 3rd transport system permease protein (AAC73949.1); Blastp hit to AAC73949.1 (238 aa), 94% identity in aa 1 - 237.
 
  
 0.964
glnP
ABC superfamily (membrane); similar to E. coli glutamine high-affinity transport system; membrane component (AAC73897.1); Blastp hit to AAC73897.1 (219 aa), 96% identity in aa 1 - 219.
  
 0.953
artJ
Arginine 3rd transport system; ABC superfamily (bind_prot); similar to E. coli arginine 3rd transport system periplasmic binding protein (AAC73947.1); Blastp hit to AAC73947.1 (243 aa), 91% identity in aa 1 - 243; Belongs to the bacterial solute-binding protein 3 family.
 
  
 0.937
gltK
Glutamate/aspartate transporter; ABC superfamily (membrane); similar to E. coli glutamate/aspartate transport system permease (AAC73754.1); Blastp hit to AAC73754.1 (224 aa), 95% identity in aa 1 - 223.
 
  
 0.914
STM1258
Putative ATPase component of ABC-type transport system; Contains duplicated ATPase domain; putative ATPase (gi|2337945).
 
    
0.904
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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