STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yfcNPutative Smr domain containing protein; Similar to E. coli orf, hypothetical protein (AAC75391.1); Blastp hit to AAC75391.1 (183 aa), 93% identity in aa 1 - 183; Belongs to the UPF0115 family. (183 aa)    
Predicted Functional Partners:
sixA
Phosphohistidine phosphatase; Similar to E. coli orf, hypothetical protein (AAC75400.1); Blastp hit to AAC75400.1 (161 aa), 89% identity in aa 1 - 161.
  
   
 0.926
dsdX
Putative Gnt family transport protein; Similar to E. coli transport system permease (serine?) (AAC75424.1); Blastp hit to AAC75424.1 (445 aa), 93% identity in aa 1 - 445.
   
  
 0.674
ydaL
Putative Smr domain protein; Similar to E. coli orf, hypothetical protein (AAC74422.1); Blastp hit to AAC74422.1 (187 aa), 86% identity in aa 1 - 187.
  
   
 0.627
metJ
Transcriptional repressor of all met genes but metF; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated (By similarity); Belongs to the MetJ family.
  
     0.618
imp
Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
  
     0.610
proQ
Activator of proP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. Belongs to the ProQ family.
  
     0.605
rplY
50S ribosomal subunit protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family.
  
 
   0.599
ygfZ
Putative aminomethyltransferase; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family.
  
     0.588
rplD
50S ribosomal subunit protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). Forms part of the polypeptide exit tunnel. Belongs to the universal ribosomal protein uL4 family.
  
 
   0.583
rpsN
30S ribosomal subunit protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family.
  
 
   0.581
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: low (28%) [HD]