| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| menG | pgtC | STM4089 | STM2398 | Putative methyltransferase in menaquinone biosynthesis protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome. | Protein for signal transmission; Required for PgtP expression, it may act jointly with the PgtA/PgtB signaling proteins. | 0.620 |
| nanM | pgtB | STM1130 | STM2397 | Putative inner membrane protein; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. | Protein for signal transmission; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. Activates PgtA by phosphorylation. | 0.655 |
| nanM | pgtC | STM1130 | STM2398 | Putative inner membrane protein; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. | Protein for signal transmission; Required for PgtP expression, it may act jointly with the PgtA/PgtB signaling proteins. | 0.686 |
| pgtA | pgtB | STM2396 | STM2397 | Activator protein; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. When activated by PgtB it acts in conjunction with sigma-54 as a transcriptional activator. | Protein for signal transmission; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. Activates PgtA by phosphorylation. | 0.998 |
| pgtA | pgtC | STM2396 | STM2398 | Activator protein; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. When activated by PgtB it acts in conjunction with sigma-54 as a transcriptional activator. | Protein for signal transmission; Required for PgtP expression, it may act jointly with the PgtA/PgtB signaling proteins. | 0.961 |
| pgtA | pgtP | STM2396 | STM2399 | Activator protein; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. When activated by PgtB it acts in conjunction with sigma-54 as a transcriptional activator. | Transporter protein; The phosphoglycerate transporter protein is a part of the PGT transport system. It is the membrane bound transporter for phosphoglycerate into salmonella. | 0.477 |
| pgtB | nanM | STM2397 | STM1130 | Protein for signal transmission; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. Activates PgtA by phosphorylation. | Putative inner membrane protein; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. | 0.655 |
| pgtB | pgtA | STM2397 | STM2396 | Protein for signal transmission; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. Activates PgtA by phosphorylation. | Activator protein; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. When activated by PgtB it acts in conjunction with sigma-54 as a transcriptional activator. | 0.998 |
| pgtB | pgtC | STM2397 | STM2398 | Protein for signal transmission; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. Activates PgtA by phosphorylation. | Protein for signal transmission; Required for PgtP expression, it may act jointly with the PgtA/PgtB signaling proteins. | 0.999 |
| pgtB | pgtP | STM2397 | STM2399 | Protein for signal transmission; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. Activates PgtA by phosphorylation. | Transporter protein; The phosphoglycerate transporter protein is a part of the PGT transport system. It is the membrane bound transporter for phosphoglycerate into salmonella. | 0.870 |
| pgtB | uhpB | STM2397 | STM3789 | Protein for signal transmission; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. Activates PgtA by phosphorylation. | Sensory histidine kinase in two-component regulatory sytem with UhpA; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpB functions as a membrane-associated protein kinase that autophosphorylates in response to interaction with UhpC, and subsequently transfers its phosphate group to the response regulator UhpA. Can also dephosphorylate UhpA. | 0.698 |
| pgtB | uhpC | STM2397 | STM3788 | Protein for signal transmission; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. Activates PgtA by phosphorylation. | Regulator of uhpT expression; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. | 0.664 |
| pgtC | menG | STM2398 | STM4089 | Protein for signal transmission; Required for PgtP expression, it may act jointly with the PgtA/PgtB signaling proteins. | Putative methyltransferase in menaquinone biosynthesis protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome. | 0.620 |
| pgtC | nanM | STM2398 | STM1130 | Protein for signal transmission; Required for PgtP expression, it may act jointly with the PgtA/PgtB signaling proteins. | Putative inner membrane protein; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. | 0.686 |
| pgtC | pgtA | STM2398 | STM2396 | Protein for signal transmission; Required for PgtP expression, it may act jointly with the PgtA/PgtB signaling proteins. | Activator protein; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. When activated by PgtB it acts in conjunction with sigma-54 as a transcriptional activator. | 0.961 |
| pgtC | pgtB | STM2398 | STM2397 | Protein for signal transmission; Required for PgtP expression, it may act jointly with the PgtA/PgtB signaling proteins. | Protein for signal transmission; Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. Activates PgtA by phosphorylation. | 0.999 |
| pgtC | pgtP | STM2398 | STM2399 | Protein for signal transmission; Required for PgtP expression, it may act jointly with the PgtA/PgtB signaling proteins. | Transporter protein; The phosphoglycerate transporter protein is a part of the PGT transport system. It is the membrane bound transporter for phosphoglycerate into salmonella. | 0.953 |
| pgtC | ugpA | STM2398 | STM3556 | Protein for signal transmission; Required for PgtP expression, it may act jointly with the PgtA/PgtB signaling proteins. | Sn-glycerol 3-phosphate transport protein; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane. | 0.660 |
| pgtC | uhpB | STM2398 | STM3789 | Protein for signal transmission; Required for PgtP expression, it may act jointly with the PgtA/PgtB signaling proteins. | Sensory histidine kinase in two-component regulatory sytem with UhpA; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpB functions as a membrane-associated protein kinase that autophosphorylates in response to interaction with UhpC, and subsequently transfers its phosphate group to the response regulator UhpA. Can also dephosphorylate UhpA. | 0.662 |
| pgtC | uhpC | STM2398 | STM3788 | Protein for signal transmission; Required for PgtP expression, it may act jointly with the PgtA/PgtB signaling proteins. | Regulator of uhpT expression; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. | 0.684 |