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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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ptsJPutative gntR family regulatory protein; Acts as transcriptional repressor of the pdxK gene, encoding a pyridoxal kinase involved in the vitamin B6 salvage pathway. Also represses transcription of its own gene. Binds to the ptsJ-pdxK intergenic region, but does not bind pdxY and pdxH promoters. Among all six B6 vitamers, only pyridoxal 5'-phosphate (PLP) clearly binds to the protein and acts as an effector molecule for PtsJ, inducing a protein conformational change that increases affinity for DNA. Thus, PLP stabilizes protein-DNA interactions, reinforcing repression. In the C-terminal [...] (430 aa)    
Predicted Functional Partners:
pdxK
Pyridoxal-pyridoxamine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. Belongs to the pyridoxine kinase family. PdxK subfamily.
  
  
 0.936
pdxH
Pyridoxine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
  
  
 0.862
pdxY
Pyridoxal kinase 2; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP.
  
  
 0.852
yfeJ
Putative GMP synthase; Contains glutamine amidotransferase domain; hypothetical 18.7 Kda protein in pdxK-cysM intergenic region. (SW:YFEJ_SALTY).
       0.788
yfeK
Putative periplasmic protein; Hypothetical 13.3 Kda protein in pdxK-cysM intergenic region. (SW:YFEK_SALTY).
       0.642
yfeL
Putative membrane carboxypeptidase; Penicillin-binding protein; hypothetical 20.5 Kda protein in pdxK-cysM intergenic region. (SW:YFEL_SALTY).
       0.638
STM2434
Putative cytoplasmic protein.
       0.569
ydcR
Putative gntR family regulatory protein; Similar to E. coli multi modular; putative transcriptional regulator; also putative ATP-binding component of a transport system (AAC74521.1); Blastp hit to AAC74521.1 (468 aa), 87% identity in aa 1 - 468.
  
   
0.463
yggS
Putative enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
  
  
 0.462
cytR
GalR/LacI family transcriptional repressor; Similar to E. coli regulator for deo operon, udp, cdd, tsx, nupC, and nupG (AAC76916.1); Blastp hit to AAC76916.1 (341 aa), 86% identity in aa 1 - 341.
      
 0.451
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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