| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| STM2434 | pdxK | STM2434 | STM2435 | Putative cytoplasmic protein. | Pyridoxal-pyridoxamine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. Belongs to the pyridoxine kinase family. PdxK subfamily. | 0.797 |
| STM2434 | ptsJ | STM2434 | STM2436 | Putative cytoplasmic protein. | Putative gntR family regulatory protein; Acts as transcriptional repressor of the pdxK gene, encoding a pyridoxal kinase involved in the vitamin B6 salvage pathway. Also represses transcription of its own gene. Binds to the ptsJ-pdxK intergenic region, but does not bind pdxY and pdxH promoters. Among all six B6 vitamers, only pyridoxal 5'-phosphate (PLP) clearly binds to the protein and acts as an effector molecule for PtsJ, inducing a protein conformational change that increases affinity for DNA. Thus, PLP stabilizes protein-DNA interactions, reinforcing repression. In the C-terminal [...] | 0.572 |
| STM2434 | yfeJ | STM2434 | STM2437 | Putative cytoplasmic protein. | Putative GMP synthase; Contains glutamine amidotransferase domain; hypothetical 18.7 Kda protein in pdxK-cysM intergenic region. (SW:YFEJ_SALTY). | 0.561 |
| STM2434 | yfeK | STM2434 | STM2438 | Putative cytoplasmic protein. | Putative periplasmic protein; Hypothetical 13.3 Kda protein in pdxK-cysM intergenic region. (SW:YFEK_SALTY). | 0.469 |
| STM2434 | yfeL | STM2434 | STM2439 | Putative cytoplasmic protein. | Putative membrane carboxypeptidase; Penicillin-binding protein; hypothetical 20.5 Kda protein in pdxK-cysM intergenic region. (SW:YFEL_SALTY). | 0.466 |
| cysA | cysM | STM2441 | STM2440 | Sulfate permease A protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. | Cysteine synthase B; Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product. | 0.958 |
| cysA | ptsJ | STM2441 | STM2436 | Sulfate permease A protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. | Putative gntR family regulatory protein; Acts as transcriptional repressor of the pdxK gene, encoding a pyridoxal kinase involved in the vitamin B6 salvage pathway. Also represses transcription of its own gene. Binds to the ptsJ-pdxK intergenic region, but does not bind pdxY and pdxH promoters. Among all six B6 vitamers, only pyridoxal 5'-phosphate (PLP) clearly binds to the protein and acts as an effector molecule for PtsJ, inducing a protein conformational change that increases affinity for DNA. Thus, PLP stabilizes protein-DNA interactions, reinforcing repression. In the C-terminal [...] | 0.495 |
| cysM | cysA | STM2440 | STM2441 | Cysteine synthase B; Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product. | Sulfate permease A protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. | 0.958 |
| cysM | ptsJ | STM2440 | STM2436 | Cysteine synthase B; Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product. | Putative gntR family regulatory protein; Acts as transcriptional repressor of the pdxK gene, encoding a pyridoxal kinase involved in the vitamin B6 salvage pathway. Also represses transcription of its own gene. Binds to the ptsJ-pdxK intergenic region, but does not bind pdxY and pdxH promoters. Among all six B6 vitamers, only pyridoxal 5'-phosphate (PLP) clearly binds to the protein and acts as an effector molecule for PtsJ, inducing a protein conformational change that increases affinity for DNA. Thus, PLP stabilizes protein-DNA interactions, reinforcing repression. In the C-terminal [...] | 0.463 |
| cytR | ptsJ | STM4094 | STM2436 | GalR/LacI family transcriptional repressor; Similar to E. coli regulator for deo operon, udp, cdd, tsx, nupC, and nupG (AAC76916.1); Blastp hit to AAC76916.1 (341 aa), 86% identity in aa 1 - 341. | Putative gntR family regulatory protein; Acts as transcriptional repressor of the pdxK gene, encoding a pyridoxal kinase involved in the vitamin B6 salvage pathway. Also represses transcription of its own gene. Binds to the ptsJ-pdxK intergenic region, but does not bind pdxY and pdxH promoters. Among all six B6 vitamers, only pyridoxal 5'-phosphate (PLP) clearly binds to the protein and acts as an effector molecule for PtsJ, inducing a protein conformational change that increases affinity for DNA. Thus, PLP stabilizes protein-DNA interactions, reinforcing repression. In the C-terminal [...] | 0.525 |
| pdxH | pdxK | STM1448 | STM2435 | Pyridoxine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | Pyridoxal-pyridoxamine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. Belongs to the pyridoxine kinase family. PdxK subfamily. | 0.973 |
| pdxH | pdxY | STM1448 | STM1450 | Pyridoxine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | Pyridoxal kinase 2; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. | 0.996 |
| pdxH | ptsJ | STM1448 | STM2436 | Pyridoxine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | Putative gntR family regulatory protein; Acts as transcriptional repressor of the pdxK gene, encoding a pyridoxal kinase involved in the vitamin B6 salvage pathway. Also represses transcription of its own gene. Binds to the ptsJ-pdxK intergenic region, but does not bind pdxY and pdxH promoters. Among all six B6 vitamers, only pyridoxal 5'-phosphate (PLP) clearly binds to the protein and acts as an effector molecule for PtsJ, inducing a protein conformational change that increases affinity for DNA. Thus, PLP stabilizes protein-DNA interactions, reinforcing repression. In the C-terminal [...] | 0.901 |
| pdxK | STM2434 | STM2435 | STM2434 | Pyridoxal-pyridoxamine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. Belongs to the pyridoxine kinase family. PdxK subfamily. | Putative cytoplasmic protein. | 0.797 |
| pdxK | pdxH | STM2435 | STM1448 | Pyridoxal-pyridoxamine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. Belongs to the pyridoxine kinase family. PdxK subfamily. | Pyridoxine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | 0.973 |
| pdxK | pdxY | STM2435 | STM1450 | Pyridoxal-pyridoxamine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. Belongs to the pyridoxine kinase family. PdxK subfamily. | Pyridoxal kinase 2; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. | 0.947 |
| pdxK | ptsJ | STM2435 | STM2436 | Pyridoxal-pyridoxamine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. Belongs to the pyridoxine kinase family. PdxK subfamily. | Putative gntR family regulatory protein; Acts as transcriptional repressor of the pdxK gene, encoding a pyridoxal kinase involved in the vitamin B6 salvage pathway. Also represses transcription of its own gene. Binds to the ptsJ-pdxK intergenic region, but does not bind pdxY and pdxH promoters. Among all six B6 vitamers, only pyridoxal 5'-phosphate (PLP) clearly binds to the protein and acts as an effector molecule for PtsJ, inducing a protein conformational change that increases affinity for DNA. Thus, PLP stabilizes protein-DNA interactions, reinforcing repression. In the C-terminal [...] | 0.951 |
| pdxK | yfeJ | STM2435 | STM2437 | Pyridoxal-pyridoxamine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. Belongs to the pyridoxine kinase family. PdxK subfamily. | Putative GMP synthase; Contains glutamine amidotransferase domain; hypothetical 18.7 Kda protein in pdxK-cysM intergenic region. (SW:YFEJ_SALTY). | 0.585 |
| pdxK | yfeK | STM2435 | STM2438 | Pyridoxal-pyridoxamine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. Belongs to the pyridoxine kinase family. PdxK subfamily. | Putative periplasmic protein; Hypothetical 13.3 Kda protein in pdxK-cysM intergenic region. (SW:YFEK_SALTY). | 0.469 |
| pdxK | yfeL | STM2435 | STM2439 | Pyridoxal-pyridoxamine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. Belongs to the pyridoxine kinase family. PdxK subfamily. | Putative membrane carboxypeptidase; Penicillin-binding protein; hypothetical 20.5 Kda protein in pdxK-cysM intergenic region. (SW:YFEL_SALTY). | 0.466 |
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