STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yfeKPutative periplasmic protein; Hypothetical 13.3 Kda protein in pdxK-cysM intergenic region. (SW:YFEK_SALTY). (126 aa)    
Predicted Functional Partners:
yfeL
Putative membrane carboxypeptidase; Penicillin-binding protein; hypothetical 20.5 Kda protein in pdxK-cysM intergenic region. (SW:YFEL_SALTY).
       0.768
yhgE
Putative inner membrane protein; Similar to E. coli putative transport (AAC76427.1); Blastp hit to AAC76427.1 (574 aa), 56% identity in aa 1 - 574.
  
     0.744
yebB
Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74932.1); Blastp hit to AAC74932.1 (233 aa), 80% identity in aa 37 - 228.
  
     0.704
ycfS
Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74197.1); Blastp hit to AAC74197.1 (320 aa), 84% identity in aa 1 - 320.
      
 0.658
ptsJ
Putative gntR family regulatory protein; Acts as transcriptional repressor of the pdxK gene, encoding a pyridoxal kinase involved in the vitamin B6 salvage pathway. Also represses transcription of its own gene. Binds to the ptsJ-pdxK intergenic region, but does not bind pdxY and pdxH promoters. Among all six B6 vitamers, only pyridoxal 5'-phosphate (PLP) clearly binds to the protein and acts as an effector molecule for PtsJ, inducing a protein conformational change that increases affinity for DNA. Thus, PLP stabilizes protein-DNA interactions, reinforcing repression. In the C-terminal [...]
       0.642
yfeJ
Putative GMP synthase; Contains glutamine amidotransferase domain; hypothetical 18.7 Kda protein in pdxK-cysM intergenic region. (SW:YFEJ_SALTY).
       0.642
ylbF
Putative cytoplasmic protein; Similar to E. coli putative carboxylase (AAC73622.1); Blastp hit to AAC73622.1 (271 aa), 65% identity in aa 1 - 269.
  
     0.610
gloA
Glyoxalase I; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
      
 0.579
ybgF
Putative periplasmic protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family.
      
 0.577
yeiU
Putative permease; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family.
      
 0.499
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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