| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| birA | yffH | STM4138 | STM2477 | biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | 0.567 |
| birA | yjeF | STM4138 | STM4356 | biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Putative sugar kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both ep [...] | 0.501 |
| ftsA | yffH | STM0132 | STM2477 | ATP-binding cell division protein; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | 0.405 |
| napC | yffH | STM2255 | STM2477 | Periplasmic nitrate reductase; Cytochrome c-type biogenesis protein; similar to E. coli cytochrome c-type protein (AAC75262.1); Blastp hit to AAC75262.1 (200 aa), 88% identity in aa 1 - 200. | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | 0.636 |
| yfeW | yffH | STM2478 | STM2477 | Similar to E. coli putative beta-lactamase (AAC75483.1); Blastp hit to AAC75483.1 (463 aa), 72% identity in aa 30 - 461; Belongs to the peptidase S12 family. YfeW subfamily. | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | 0.510 |
| yffH | birA | STM2477 | STM4138 | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.567 |
| yffH | ftsA | STM2477 | STM0132 | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | ATP-binding cell division protein; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. | 0.405 |
| yffH | napC | STM2477 | STM2255 | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | Periplasmic nitrate reductase; Cytochrome c-type biogenesis protein; similar to E. coli cytochrome c-type protein (AAC75262.1); Blastp hit to AAC75262.1 (200 aa), 88% identity in aa 1 - 200. | 0.636 |
| yffH | yfeW | STM2477 | STM2478 | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | Similar to E. coli putative beta-lactamase (AAC75483.1); Blastp hit to AAC75483.1 (463 aa), 72% identity in aa 30 - 461; Belongs to the peptidase S12 family. YfeW subfamily. | 0.510 |
| yffH | ygbL | STM2477 | STM2916 | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | Similar to E. coli putative epimerase/aldolase (AAC75780.1); Blastp hit to AAC75780.1 (212 aa), 85% identity in aa 1 - 211. | 0.451 |
| yffH | yjaB | STM2477 | STM4181 | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | Putative acetyltransferase; N-epsilon-lysine acetyltransferase that catalyzes acetylation of a large number of proteins; Belongs to the acetyltransferase family. | 0.643 |
| yffH | yjeF | STM2477 | STM4356 | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | Putative sugar kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both ep [...] | 0.537 |
| yffH | ypfG | STM2477 | STM2476 | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75519.1); Blastp hit to AAC75519.1 (347 aa), 77% identity in aa 1 - 347. | 0.541 |
| yffH | yqiB | STM2477 | STM3184 | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | Putative cytoplasmic protein; Similar to E. coli putative enzyme (AAC76069.1); Blastp hit to AAC76069.1 (140 aa), 95% identity in aa 1 - 140. | 0.554 |
| yffH | yrfI | STM2477 | STM3498 | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | Heat shock protein 33; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. | 0.464 |
| ygbL | yffH | STM2916 | STM2477 | Similar to E. coli putative epimerase/aldolase (AAC75780.1); Blastp hit to AAC75780.1 (212 aa), 85% identity in aa 1 - 211. | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | 0.451 |
| yjaB | yffH | STM4181 | STM2477 | Putative acetyltransferase; N-epsilon-lysine acetyltransferase that catalyzes acetylation of a large number of proteins; Belongs to the acetyltransferase family. | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | 0.643 |
| yjeF | birA | STM4356 | STM4138 | Putative sugar kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both ep [...] | biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.501 |
| yjeF | yffH | STM4356 | STM2477 | Putative sugar kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both ep [...] | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | 0.537 |
| ypfG | yffH | STM2476 | STM2477 | Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75519.1); Blastp hit to AAC75519.1 (347 aa), 77% identity in aa 1 - 347. | Putative pyrophosphohydrolase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. | 0.541 |
