dapE protein (Salmonella enterica Typhimurium)

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dapE

N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily. (375 aa)

Predicted Functional Partners:

dapF

0.956

bglA

0.953

yffB

0.946

argD

0.920

dapD

0.871

ypfN

0.719

prsA

0.706

rof

0.652

yfcB

0.646

yfdZ

0.617

Your Current Organism:

Salmonella enterica Typhimurium

NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
argD	dapD	STM3468	STM0213	Acetylornithine transaminase; Involved in both the arginine and lysine biosynthetic pathways.	Similar to E. coli 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase (AAC73277.1); Blastp hit to AAC73277.1 (274 aa), 97% identity in aa 1 - 274; Belongs to the transferase hexapeptide repeat family.	0.935
argD	dapE	STM3468	STM2483	Acetylornithine transaminase; Involved in both the arginine and lysine biosynthetic pathways.	N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily.	0.920
bglA	dapE	STM3051	STM2483	Similar to E. coli 6-phospho-beta-glucosidase A; cryptic (AAC75939.1); Blastp hit to AAC75939.1 (479 aa), 95% identity in aa 3 - 479; Belongs to the glycosyl hydrolase 1 family.	N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily.	0.953
dapD	argD	STM0213	STM3468	Similar to E. coli 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase (AAC73277.1); Blastp hit to AAC73277.1 (274 aa), 97% identity in aa 1 - 274; Belongs to the transferase hexapeptide repeat family.	Acetylornithine transaminase; Involved in both the arginine and lysine biosynthetic pathways.	0.935
dapD	dapE	STM0213	STM2483	Similar to E. coli 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase (AAC73277.1); Blastp hit to AAC73277.1 (274 aa), 97% identity in aa 1 - 274; Belongs to the transferase hexapeptide repeat family.	N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily.	0.871
dapD	dapF	STM0213	STM3947	Similar to E. coli 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase (AAC73277.1); Blastp hit to AAC73277.1 (274 aa), 97% identity in aa 1 - 274; Belongs to the transferase hexapeptide repeat family.	Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.	0.749
dapD	yfdZ	STM0213	STM2402	Similar to E. coli 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase (AAC73277.1); Blastp hit to AAC73277.1 (274 aa), 97% identity in aa 1 - 274; Belongs to the transferase hexapeptide repeat family.	Similar to E. coli putative aminotransferase (AAC75438.1); Blastp hit to AAC75438.1 (412 aa), 95% identity in aa 1 - 412.	0.616
dapE	argD	STM2483	STM3468	N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily.	Acetylornithine transaminase; Involved in both the arginine and lysine biosynthetic pathways.	0.920
dapE	bglA	STM2483	STM3051	N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily.	Similar to E. coli 6-phospho-beta-glucosidase A; cryptic (AAC75939.1); Blastp hit to AAC75939.1 (479 aa), 95% identity in aa 3 - 479; Belongs to the glycosyl hydrolase 1 family.	0.953
dapE	dapD	STM2483	STM0213	N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily.	Similar to E. coli 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase (AAC73277.1); Blastp hit to AAC73277.1 (274 aa), 97% identity in aa 1 - 274; Belongs to the transferase hexapeptide repeat family.	0.871
dapE	dapF	STM2483	STM3947	N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily.	Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.	0.956
dapE	prsA	STM2483	STM1780	N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily.	Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).	0.706
dapE	rof	STM2483	STM0237	N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily.	Modulator of Rho-dependent transcription termination; Similar to E. coli orf, hypothetical protein (AAC73300.1); Blastp hit to AAC73300.1 (86 aa), 81% identity in aa 1 - 86.	0.652
dapE	yfcB	STM2483	STM2385	N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily.	Putative methylase; Specifically methylates the 50S ribosomal protein L3 on 'Gln- 150'; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.	0.646
dapE	yfdZ	STM2483	STM2402	N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily.	Similar to E. coli putative aminotransferase (AAC75438.1); Blastp hit to AAC75438.1 (412 aa), 95% identity in aa 1 - 412.	0.617
dapE	yffB	STM2483	STM2482	N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily.	Putative glutaredoxin family protein; Similar to E. coli orf, hypothetical protein (AAC75524.1); Blastp hit to AAC75524.1 (118 aa), 80% identity in aa 1 - 118; Belongs to the ArsC family.	0.946
dapE	ypfN	STM2483	STM2484	N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily.	Putative inner membrane protein.	0.719
dapF	dapD	STM3947	STM0213	Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.	Similar to E. coli 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase (AAC73277.1); Blastp hit to AAC73277.1 (274 aa), 97% identity in aa 1 - 274; Belongs to the transferase hexapeptide repeat family.	0.749
dapF	dapE	STM3947	STM2483	Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.	N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily.	0.956
prsA	dapE	STM1780	STM2483	Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).	N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. Can also hydrolyze all N-terminal Asp dipeptides except Asp-Pro. Asp-Ser is the best substrate, followed by Asp-Gly, Asp-Leu, and Asp- Cys; Belongs to the peptidase M20A family. DapE subfamily.	0.706

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