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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sinHSinH; Similar to Escherichia coli intimin and Yersinia pestis invasin proteins; (gi|4583531). (730 aa)    
Predicted Functional Partners:
ratB
Putative outer membrane protein; RatB (gi|5107806).
     
 0.932
misL
Putative autotransported protein; Pathogenicity island encoded protein: SPI3; MisL (gi|4324610).
      
 0.899
shdA
C-terminal region of AIDA-like protein; IcsA; subspecies I specific; Peyer's patch colonization and shedding factor; ShdA (gi|5107805).
      
 0.897
sinI
Putative outer membrane protein; SinI (gi|4583530).
  
  
0.745
bcfD
Fimbrial subunit (gi|4959514).
      
 0.671
ratA
Putative outer membrane protein; RatA (gi|4583529).
  
  
 0.585
ftsK
Cell division protein; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA trans [...]
   
 
 0.575
avrA
Putative inner membrane protein.
      
 0.508
pagN
Homolog of sapA; Haemagglutinin that facilitates the adhesion to and invasion of epithelial mammalian cells. Utilizes heparinated proteoglycan as a receptor to successfully invade host cells.
   
  
 0.471
sseI
Gifsy-2 prophage putative type III secreted protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required to maintain a long-term chronic systemic infection in mice. It inhibits normal cell migration of primary macrophages and dendritic cells, by a mechanism that involves interaction with the host factor IQGAP1, an important regulator of the cytoskeleton and cell migration. Also accelerates the systemic spread of infection from the gastrointestinal tract to the bloodstream, probably by interacting with host TRIP6.
      
 0.465
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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