| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| avrA | misL | STM2865 | STM3757 | Putative inner membrane protein. | Putative autotransported protein; Pathogenicity island encoded protein: SPI3; MisL (gi|4324610). | 0.672 |
| avrA | ratB | STM2865 | STM2514 | Putative inner membrane protein. | Putative outer membrane protein; RatB (gi|5107806). | 0.660 |
| avrA | sinH | STM2865 | STM2517 | Putative inner membrane protein. | SinH; Similar to Escherichia coli intimin and Yersinia pestis invasin proteins; (gi|4583531). | 0.508 |
| avrA | sseI | STM2865 | STM1051 | Putative inner membrane protein. | Gifsy-2 prophage putative type III secreted protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required to maintain a long-term chronic systemic infection in mice. It inhibits normal cell migration of primary macrophages and dendritic cells, by a mechanism that involves interaction with the host factor IQGAP1, an important regulator of the cytoskeleton and cell migration. Also accelerates the systemic spread of infection from the gastrointestinal tract to the bloodstream, probably by interacting with host TRIP6. | 0.834 |
| bcfD | ratB | STM0024 | STM2514 | Fimbrial subunit (gi|4959514). | Putative outer membrane protein; RatB (gi|5107806). | 0.572 |
| bcfD | shdA | STM0024 | STM2513 | Fimbrial subunit (gi|4959514). | C-terminal region of AIDA-like protein; IcsA; subspecies I specific; Peyer's patch colonization and shedding factor; ShdA (gi|5107805). | 0.455 |
| bcfD | sinH | STM0024 | STM2517 | Fimbrial subunit (gi|4959514). | SinH; Similar to Escherichia coli intimin and Yersinia pestis invasin proteins; (gi|4583531). | 0.671 |
| ftsK | ratA | STM0960 | STM2515 | Cell division protein; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA trans [...] | Putative outer membrane protein; RatA (gi|4583529). | 0.575 |
| ftsK | ratB | STM0960 | STM2514 | Cell division protein; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA trans [...] | Putative outer membrane protein; RatB (gi|5107806). | 0.575 |
| ftsK | sinH | STM0960 | STM2517 | Cell division protein; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA trans [...] | SinH; Similar to Escherichia coli intimin and Yersinia pestis invasin proteins; (gi|4583531). | 0.575 |
| misL | avrA | STM3757 | STM2865 | Putative autotransported protein; Pathogenicity island encoded protein: SPI3; MisL (gi|4324610). | Putative inner membrane protein. | 0.672 |
| misL | pagN | STM3757 | STM0306 | Putative autotransported protein; Pathogenicity island encoded protein: SPI3; MisL (gi|4324610). | Homolog of sapA; Haemagglutinin that facilitates the adhesion to and invasion of epithelial mammalian cells. Utilizes heparinated proteoglycan as a receptor to successfully invade host cells. | 0.699 |
| misL | ratB | STM3757 | STM2514 | Putative autotransported protein; Pathogenicity island encoded protein: SPI3; MisL (gi|4324610). | Putative outer membrane protein; RatB (gi|5107806). | 0.900 |
| misL | shdA | STM3757 | STM2513 | Putative autotransported protein; Pathogenicity island encoded protein: SPI3; MisL (gi|4324610). | C-terminal region of AIDA-like protein; IcsA; subspecies I specific; Peyer's patch colonization and shedding factor; ShdA (gi|5107805). | 0.589 |
| misL | sinH | STM3757 | STM2517 | Putative autotransported protein; Pathogenicity island encoded protein: SPI3; MisL (gi|4324610). | SinH; Similar to Escherichia coli intimin and Yersinia pestis invasin proteins; (gi|4583531). | 0.899 |
| pagN | misL | STM0306 | STM3757 | Homolog of sapA; Haemagglutinin that facilitates the adhesion to and invasion of epithelial mammalian cells. Utilizes heparinated proteoglycan as a receptor to successfully invade host cells. | Putative autotransported protein; Pathogenicity island encoded protein: SPI3; MisL (gi|4324610). | 0.699 |
| pagN | shdA | STM0306 | STM2513 | Homolog of sapA; Haemagglutinin that facilitates the adhesion to and invasion of epithelial mammalian cells. Utilizes heparinated proteoglycan as a receptor to successfully invade host cells. | C-terminal region of AIDA-like protein; IcsA; subspecies I specific; Peyer's patch colonization and shedding factor; ShdA (gi|5107805). | 0.457 |
| pagN | sinH | STM0306 | STM2517 | Homolog of sapA; Haemagglutinin that facilitates the adhesion to and invasion of epithelial mammalian cells. Utilizes heparinated proteoglycan as a receptor to successfully invade host cells. | SinH; Similar to Escherichia coli intimin and Yersinia pestis invasin proteins; (gi|4583531). | 0.471 |
| pagN | sseI | STM0306 | STM1051 | Homolog of sapA; Haemagglutinin that facilitates the adhesion to and invasion of epithelial mammalian cells. Utilizes heparinated proteoglycan as a receptor to successfully invade host cells. | Gifsy-2 prophage putative type III secreted protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required to maintain a long-term chronic systemic infection in mice. It inhibits normal cell migration of primary macrophages and dendritic cells, by a mechanism that involves interaction with the host factor IQGAP1, an important regulator of the cytoskeleton and cell migration. Also accelerates the systemic spread of infection from the gastrointestinal tract to the bloodstream, probably by interacting with host TRIP6. | 0.457 |
| ratA | ftsK | STM2515 | STM0960 | Putative outer membrane protein; RatA (gi|4583529). | Cell division protein; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA trans [...] | 0.575 |