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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pepBPutative aminopeptidase; Probably plays an important role in intracellular peptide degradation; Belongs to the peptidase M17 family. (427 aa)    
Predicted Functional Partners:
pepD
Similar to E. coli aminoacyl-histidine dipeptidase (peptidase D) (AAC73341.1); Blastp hit to AAC73341.1 (485 aa), 92% identity in aa 1 - 485.
   
 
 0.970
pepN
Similar to E. coli aminopeptidase N (AAC74018.1); Blastp hit to AAC74018.1 (870 aa), 94% identity in aa 1 - 870.
   
 0.940
gshB
Similar to E. coli glutathione synthetase (AAC75984.1); Blastp hit to AAC75984.1 (316 aa), 90% identity in aa 1 - 313.
   
 
 0.936
pepA
Aminopeptidase A; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.
  
 
0.931
gshA
Glutamate--cysteine ligase. (SW:GSH1_SALTY); Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
   
 
 0.923
ggt
Similar to E. coli gamma-glutamyltranspeptidase (AAC76472.1); Blastp hit to AAC76472.1 (580 aa), 91% identity in aa 2 - 580.
     
 0.916
iadA
Isoaspartyl dipeptidase; Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.
     
 0.901
ybdK
Putative cytoplasmic protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
     
  0.900
yfhJ
Hypothetical protein; Believed to be involved in assembly of Fe-S clusters; similar to E. coli orf, hypothetical protein (AAC75577.1); Blastp hit to AAC75577.1 (66 aa), 92% identity in aa 1 - 66.
 
    0.882
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).
  
 
 0.823
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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