| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| STM1060 | hmpA | STM1060 | STM2556 | Putative iron-sulfur protein; Similar to E. coli orf, hypothetical protein (AAC74033.1); Blastp hit to AAC74033.1 (369 aa), 86% identity in aa 1 - 367. | Dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Belongs to the globin family. Two-domain flavohemoproteins subfamily. | 0.852 |
| STM1060 | nirB | STM1060 | STM3474 | Putative iron-sulfur protein; Similar to E. coli orf, hypothetical protein (AAC74033.1); Blastp hit to AAC74033.1 (369 aa), 86% identity in aa 1 - 367. | Similar to E. coli nitrite reductase (NAD(P)H) subunit (AAC76390.1); Blastp hit to AAC76390.1 (847 aa), 95% identity in aa 1 - 847; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.547 |
| STM1808 | hmpA | STM1808 | STM2556 | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74867.1); Blastp hit to AAC74867.1 (119 aa), 42% identity in aa 2 - 113. | Dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Belongs to the globin family. Two-domain flavohemoproteins subfamily. | 0.841 |
| STM1808 | yjeB | STM1808 | STM4367 | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74867.1); Blastp hit to AAC74867.1 (119 aa), 42% identity in aa 2 - 113. | Putative negative regulator; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. Represses hmp expression under conditions of elevated intracellular iron concentrations, in the absence of nitric oxide. | 0.705 |
| STM1808 | ytfE | STM1808 | STM4399 | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74867.1); Blastp hit to AAC74867.1 (119 aa), 42% identity in aa 2 - 113. | Putative cell morphogenesis; Di-iron-containing protein involved in the repair of iron- sulfur clusters damaged by oxidative and nitrosative stress conditions. | 0.882 |
| hcp | hmpA | STM0937 | STM2556 | Hybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | Dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Belongs to the globin family. Two-domain flavohemoproteins subfamily. | 0.907 |
| hcp | nirB | STM0937 | STM3474 | Hybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | Similar to E. coli nitrite reductase (NAD(P)H) subunit (AAC76390.1); Blastp hit to AAC76390.1 (847 aa), 95% identity in aa 1 - 847; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.982 |
| hcp | norV | STM0937 | STM2840 | Hybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | Putative flavoprotein; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family. | 0.903 |
| hcp | nrfA | STM0937 | STM4277 | Hybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | Nitrite reductase periplasmic cytochrome c(552); Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. | 0.983 |
| hcp | yjeB | STM0937 | STM4367 | Hybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | Putative negative regulator; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. Represses hmp expression under conditions of elevated intracellular iron concentrations, in the absence of nitric oxide. | 0.532 |
| hcp | ytfE | STM0937 | STM4399 | Hybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | Putative cell morphogenesis; Di-iron-containing protein involved in the repair of iron- sulfur clusters damaged by oxidative and nitrosative stress conditions. | 0.831 |
| hmpA | STM1060 | STM2556 | STM1060 | Dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Belongs to the globin family. Two-domain flavohemoproteins subfamily. | Putative iron-sulfur protein; Similar to E. coli orf, hypothetical protein (AAC74033.1); Blastp hit to AAC74033.1 (369 aa), 86% identity in aa 1 - 367. | 0.852 |
| hmpA | STM1808 | STM2556 | STM1808 | Dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Belongs to the globin family. Two-domain flavohemoproteins subfamily. | Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC74867.1); Blastp hit to AAC74867.1 (119 aa), 42% identity in aa 2 - 113. | 0.841 |
| hmpA | hcp | STM2556 | STM0937 | Dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Belongs to the globin family. Two-domain flavohemoproteins subfamily. | Hybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | 0.907 |
| hmpA | nirB | STM2556 | STM3474 | Dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Belongs to the globin family. Two-domain flavohemoproteins subfamily. | Similar to E. coli nitrite reductase (NAD(P)H) subunit (AAC76390.1); Blastp hit to AAC76390.1 (847 aa), 95% identity in aa 1 - 847; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.884 |
| hmpA | norV | STM2556 | STM2840 | Dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Belongs to the globin family. Two-domain flavohemoproteins subfamily. | Putative flavoprotein; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family. | 0.974 |
| hmpA | nrfA | STM2556 | STM4277 | Dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Belongs to the globin family. Two-domain flavohemoproteins subfamily. | Nitrite reductase periplasmic cytochrome c(552); Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family. | 0.954 |
| hmpA | yfhP | STM2556 | STM2544 | Dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Belongs to the globin family. Two-domain flavohemoproteins subfamily. | Hypothetical protein; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.834 |
| hmpA | ygaA | STM2556 | STM2839 | Dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Belongs to the globin family. Two-domain flavohemoproteins subfamily. | Putative EBP family regulator; Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54. | 0.942 |
| hmpA | yjeB | STM2556 | STM4367 | Dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Belongs to the globin family. Two-domain flavohemoproteins subfamily. | Putative negative regulator; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity. Represses hmp expression under conditions of elevated intracellular iron concentrations, in the absence of nitric oxide. | 0.987 |
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