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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STM2724Fels-2 prophage protein. (583 aa)    
Predicted Functional Partners:
STM2729
Fels-2 prophage protein; Possible endonuclease which induces a single-strand cut and initiates DNA replication.
  
  
 0.959
STM2722
Fels-2 prophage protein; Similar to gpP; ATP charging in phage P2.
   
  
 0.945
STM2730
Fels-2 prophage protein; Similar to retron in E coli; similar to E. coli DNA adenine methylase (AAC76412.1); Blastp hit to AAC76412.1 (278 aa), 46% identity in aa 8 - 266.
  
  
 0.940
STM0903
Putative Fels-1 prophage chaparone; Similar to E. coli orf, hypothetical protein (AAC74632.1); Blastp hit to AAC74632.1 (260 aa), 38% identity in aa 11 - 130, 37% identity in aa 152 - 259, 35% identity in aa 121 - 165, 58% identity in aa 123 - 134, 40-1073758628dentity in aa 168 - 187.
   
  
 0.881
STM0893
Putative Fels-1 prophage integrase; Similar to E. coli putative transposase (AAC74651.1); Blastp hit to AAC74651.1 (398 aa), 55% identity in aa 2 - 398; Belongs to the 'phage' integrase family.
   
  
 0.873
STM2703
Fels-2 prophage protein; Similar to invertase (pin) in phage E14; unknown (gi|2852344).
   
    0.854
gyrA
DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state, and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. Replenishes negative supercoiling downstream of highly transcribed genes to help control overall chromosomal supercoiling density. E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB s [...]
  
 
 0.817
parC
DNA topoisomerase IV, subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
  
 
 0.817
STM2738
Fels-2 prophage protein; Similar to E. coli retron.
   
    0.752
STM0913
Fels-1 prophage protein.
   
    0.748
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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