Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mig-14Putative transcription activator. (298 aa)    
Predicted Functional Partners:
virK
virK-like protein; Similar to virK in Shigella; virulence gene; similar to E. coli putative enzyme (AAC73964.1); Blastp hit to AAC73964.1 (330 aa), 39% identity in aa 47 - 329.
  
  
 0.986
pagK
PhoPQ-activated protein; PagK (gi|2582047).
   
  
 0.768
yedP
Putative hydrolase of the HAD superfamily; Similar to E. coli orf, hypothetical protein (AAC75021.1); Blastp hit to AAC75021.1 (271 aa), 75% identity in aa 1 - 269.
      
 0.767
pmrD
Polymyxin resistance protein B; Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance; Belongs to the PmrD family.
   
  
 0.742
ugtL
Putative membrane protein; Homology with chitinase from Schizosaccharomyces; putative membrane protein UgtL (gi|4585341).
   
  
 0.727
phoP
Response regulator in two-component regulatory system with PhoQ; Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repressio [...]
   
  
 0.683
pagD
PhoP regulated; Putative function in virulence. Could be involved in promoting S.typhimurium survival within macrophages.
      
 0.677
mgtC
Mg2+ transport protein; Virulence factor required for growth in low Mg(2+) medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na(+)/K(+)-ATPase. Belongs to the MgtC/SapB family.
      
 0.673
ybjX
Homolog of virK; Similar to E. coli putative enzyme (AAC73964.1); Blastp hit to AAC73964.1 (330 aa), 57% identity in aa 15 - 329.
   
  
 0.632
sinH
SinH; Similar to Escherichia coli intimin and Yersinia pestis invasin proteins; (gi|4583531).
      
 0.620
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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