STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nxiAPutative nickel transporter; Efflux system for nickel and cobalt. (337 aa)    
Predicted Functional Partners:
hypF
Hydrogenase maturation protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
      0.586
nikR
Nickel-responsive transcriptional regulator; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel.
     
 0.578
STM0356
Similar to E. coli putative transport protein (AAC77235.1); Blastp hit to AAC77235.1 (425 aa), 28% identity in aa 33 - 412.
  
    0.568
yaaA
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC73117.1); Blastp hit to AAC73117.1 (258 aa), 86% identity in aa 1 - 257; Belongs to the UPF0246 family.
 
      0.556
STM1678
Putative 2'-hydroxyisoflavone reductase.
  
     0.548
fabF
3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
 
      0.512
iroC
Putative ATP binding cassette (ABC) transporter; Similar to E. coli ATP-binding transport protein; multicopy suppressor of htrB (AAC74000.1); Blastp hit to AAC74000.1 (582 aa), 26% identity in aa 14 - 582, 29% identity in aa 34 - 565.
      
 0.511
tctE
Tricarboxylic transport regulatory protein; Similar to E. coli putative 2-component sensor protein (AAC76062.1); Blastp hit to AAC76062.1 (449 aa), 30% identity in aa 160 - 447, 29% identity in aa 1 - 56.
  
    0.507
tctD
Tricarboxylic transport regulatory protein; Transcriptional activator of the tctI tricarboxylate transport system operon.
  
    0.501
fabB
Similar to E. coli 3-oxoacyl-[acyl-carrier-protein] synthase I (AAC75383.1); Blastp hit to AAC75383.1 (406 aa), 96% identity in aa 1 - 404; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
      0.405
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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