STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
emrRTranscriptional repressor of emrAB operon; MarR family; similar to E. coli regulator of plasmid mcrB operon (microcin B17 synthesis) (AAC75731.1); Blastp hit to AAC75731.1 (176 aa), 93% identity in aa 1 - 175. (176 aa)    
Predicted Functional Partners:
emrA
Similar to E. coli multidrug resistance secretion protein (AAC75732.1); Blastp hit to AAC75732.1 (390 aa), 89% identity in aa 1 - 390.
 
  
 0.965
emrB
Putative MFS superfamily multidrug transport protein; Similar to E. coli multidrug resistance; probably membrane translocase (AAC75733.1); Blastp hit to AAC75733.1 (512 aa), 95% identity in aa 1 - 512; Belongs to the major facilitator superfamily.
 
   
 0.959
ydhE
Putative MATE family transport protein; Multidrug efflux pump that functions probably as a Na(+)/drug antiporter; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
  
  
 0.776
marA
AraC/XylS family transcriptional activator of defense systems; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF.
   
  
 0.771
mdfA
Multidrug translocase; Similar to E. coli proton motive force efflux pump (AAC73929.1); Blastp hit to AAC73929.1 (410 aa), 90% identity in aa 1 - 406.
 
   
 0.770
acrA
Similar to E. coli acridine efflux pump (AAC73565.1); Blastp hit to AAC73565.1 (397 aa), 91% identity in aa 1 - 397; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
  
 0.723
ydhJ
Putative multidrug resistance efflux pump; Similar to E. coli putative membrane protein (AAC74716.1); Blastp hit to AAC74716.1 (299 aa), 83% identity in aa 9 - 299; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
  
 0.690
wecF-2
Putative inner membrane protein; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family.
  
     0.656
slyA
MarR family transcriptional regulator for hemolysin; Transcription regulator that can specifically activate or repress expression of target genes. Required for virulence and survival in the macrophage environment. Probably activates expression of ispA, xseB genes, and of omp operon.
  
  
 0.623
crp
Catabolite activator protein (CAP); A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity).
   
  
 0.619
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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