Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hydNSimilar to E. coli involved in electron transport from formate to hydrogen, Fe-S centers (AAC75755.1); Blastp hit to AAC75755.1 (175 aa), 95% identity in aa 1 - 173. (181 aa)    
Predicted Functional Partners:
hypF
Hydrogenase maturation protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
  
  
 0.942
hycE
Part of FHL complex; similar to E. coli large subunit of hydrogenase 3 (part of FHL complex) (AAC75763.1); Blastp hit to AAC75763.1 (569 aa), 97% identity in aa 1 - 569.
 
   0.881
gltD
Similar to E. coli glutamate synthase, small subunit (AAC76245.1); Blastp hit to AAC76245.1 (472 aa), 95% identity in aa 1 - 472.
  
   0.833
hycI
Similar to E. coli protease involved in processing C-terminal end of the large subunit of hydrogenase 3 (AAC75759.1); Blastp hit to AAC75759.1 (156 aa), 91% identity in aa 1 - 155.
    0.810
nifJ
Similar to E. coli putative oxidoreductase, Fe-S subunit (AAC74460.1); Blastp hit to AAC74460.1 (1174 aa), 92% identity in aa 1 - 1174.
  
 
 0.804
hycF
Hydrogenase 3; Similar to E. coli probable iron-sulfur protein of hydrogenase 3 (part of FHL complex) (AAC75762.1); Blastp hit to AAC75762.1 (180 aa), 96% identity in aa 1 - 178; putative quinone oxidoreductase.
 
 
 0.782
hycG
Similar to E. coli hydrogenase activity (AAC75761.1); Blastp hit to AAC75761.1 (255 aa), 96% identity in aa 1 - 255.
 
 0.771
hycD
Hydrogenase 3, membrane subunit; Part of FHL complex; similar to E. coli membrane-spanning protein of hydrogenase 3 (part of FHL complex) (AAC75764.1); Blastp hit to AAC75764.1 (307 aa), 90% identity in aa 1 - 307.
 
 
 0.748
fdhF
Formate dehydrogenase; Similar to E. coli selenopolypeptide subunit of formate dehydrogenase H (AAD13462.1); Blastp hit to AAD13462.1 (715 aa), 97% identity in aa 1 - 714; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
 
 0.704
STM1538
Similar to E. coli hydrogenase-1 large subunit (AAC74058.1); Blastp hit to AAC74058.1 (597 aa), 66% identity in aa 1 - 597.
      
 0.674
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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