STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hycASimilar to E. coli transcriptional repression of hyc and hyp operons (AAC75767.1); Blastp hit to AAC75767.1 (153 aa), 88% identity in aa 1 - 152. (153 aa)    
Predicted Functional Partners:
hycE
Part of FHL complex; similar to E. coli large subunit of hydrogenase 3 (part of FHL complex) (AAC75763.1); Blastp hit to AAC75763.1 (569 aa), 97% identity in aa 1 - 569.
  
  
 0.956
hycB
Hydrogenase-3, iron-sulfur subunit; Part of FHL complex; similar to E. coli probable small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) (AAC75766.1); Blastp hit to AAC75766.1 (203 aa), 95% identity in aa 1 - 202.
  
  
 0.921
hycH
Protein for processing of HycE; Part of the FHL complex; similar to E. coli processing of large subunit (HycE) of hydrogenase 3 (part of the FHL complex) (AAC75760.1); Blastp hit to AAC75760.1 (136 aa), 91% identity in aa 1 - 136.
  
  
 0.887
fdhF
Formate dehydrogenase; Similar to E. coli selenopolypeptide subunit of formate dehydrogenase H (AAD13462.1); Blastp hit to AAD13462.1 (715 aa), 97% identity in aa 1 - 714; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
   
  
 0.815
hycI
Similar to E. coli protease involved in processing C-terminal end of the large subunit of hydrogenase 3 (AAC75759.1); Blastp hit to AAC75759.1 (156 aa), 91% identity in aa 1 - 155.
  
  
 0.807
hycD
Hydrogenase 3, membrane subunit; Part of FHL complex; similar to E. coli membrane-spanning protein of hydrogenase 3 (part of FHL complex) (AAC75764.1); Blastp hit to AAC75764.1 (307 aa), 90% identity in aa 1 - 307.
  
  
 0.797
hycC
Hydrogenase 3, membrane subunit; Part of FHL complex; similar to E. coli membrane-spanning protein of hydrogenase 3 (part of FHL complex) (AAC75765.1); Blastp hit to AAC75765.1 (608 aa), 88% identity in aa 1 - 608.
  
  
 0.797
hycG
Similar to E. coli hydrogenase activity (AAC75761.1); Blastp hit to AAC75761.1 (255 aa), 96% identity in aa 1 - 255.
  
  
 0.778
hypA
Guanine-nucleotide binding protein in formate-hydrogenlyase system; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
  
  
 0.718
hycF
Hydrogenase 3; Similar to E. coli probable iron-sulfur protein of hydrogenase 3 (part of FHL complex) (AAC75762.1); Blastp hit to AAC75762.1 (180 aa), 96% identity in aa 1 - 178; putative quinone oxidoreductase.
  
  
 0.670
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.