Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hypBHydrogenase-3 accessory protein; Assembly of metallocenter; similar to E. coli guanine-nucleotide binding protein, functions as nickel donor for large subunit of hydrogenase 3 (AAC75769.1); Blastp hit to AAC75769.1 (290 aa), 94% identity in aa 1 - 290. (290 aa)    
Predicted Functional Partners:
hypA
Guanine-nucleotide binding protein in formate-hydrogenlyase system; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.999
hypC
Putative hydrogenase expression/formation protein; Similar to E. coli pleiotrophic effects on 3 hydrogenase isozymes (AAC75770.1); Blastp hit to AAC75770.1 (90 aa), 96% identity in aa 1 - 90.
  
 0.999
hypD
Putative hydrogenase expression/formation protein; Similar to E. coli pleiotrophic effects on 3 hydrogenase isozymes (AAC75771.1); Blastp hit to AAC75771.1 (373 aa), 94% identity in aa 1 - 372; Belongs to the HypD family.
 
  
 0.998
hypA-2
Putative hydrogenase; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.990
hypE
Putative hydrogenase expression/formation protein; Similar to E. coli plays structural role in maturation of all 3 hydrogenases (AAC75772.1); Blastp hit to AAC75772.1 (322 aa), 91% identity in aa 1 - 322.
 
  
 0.986
hypF
Hydrogenase maturation protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
  
 0.983
hycE
Part of FHL complex; similar to E. coli large subunit of hydrogenase 3 (part of FHL complex) (AAC75763.1); Blastp hit to AAC75763.1 (569 aa), 97% identity in aa 1 - 569.
 
 
 
 0.979
hybF
Putative hydrogenase expression/formation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.942
slyD
Similar to E. coli FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) (AAC76374.1); Blastp hit to AAC76374.1 (196 aa), 97% identity in aa 1 - 196.
    
 
 0.930
yeiR
Putative cobalamin synthesis protein; Similar to E. coli orf, hypothetical protein (AAC75234.1); Blastp hit to AAC75234.1 (328 aa), 87% identity in aa 1 - 328.
      
 0.871
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
Server load: medium (62%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.