Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sprBTranscriptional regulator SprB (gi|5007028). (251 aa)    
Predicted Functional Partners:
hilC
araC family bacterial regulatory helix-turn-helix protein; Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1).
  
  
 0.997
hilD
Regulatory helix-turn-helix proteins, araC family; HilD (gi|4455108).
  
  
 0.911
invF
Invasion protein; Transcriptional regulator required for the expression of several genes encoding type III secretion system SPI1 effector proteins. The interaction with SicA is necessary for the activation of sigDE (sopB pipC), sicAsipBCDA, and sopE.
   
  
 0.859
avrA
Putative inner membrane protein.
  
  
 0.855
hilA
Invasion genes transcription activator; The main transcriptional regulator of the Salmonella pathogenicity island 1 (SPI1) gene expression. Activates the expression of invasion genes by a direct action at their promoters and also indirectly by increasing the level of InvF. Also binds upstream of prgH and directly activates the expression of prgHIJK operon.
   
  
 0.818
invH
Invasion protein; Involved in the synthesis of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Pilot protein that is required for the proper localization of the secretin InvG/SctC in the outer membrane. Required for the secretion of the Sip virulence factors.
   
  
 0.814
prgH
Cell invasion protein; Required for invasion of epithelial cells.
  
  
 0.778
invJ
Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells; Belongs to the SpaN family.
   
  
 0.759
spaP
Surface presentation of antigens; Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells.
   
  
 0.714
sicA
Surface presentation of antigens; Type III secretion-associated chaperone required for SipB and SipC stabilization. Prevents premature association of SipB with SipC, which may lead to their targeting for degradation. Along with InvF, required for transcription activation of sigDE (sopB pipC), sicAsipBCDA, and sopE.
   
  
 0.710
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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