Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gudDD-glucarate dehydratase; Similar to E. coli putative glucarate dehydratase (AAC75829.1); Blastp hit to AAC75829.1 (446 aa), 97% identity in aa 1 - 446. (446 aa)    
Predicted Functional Partners:
garD
Galactarate dehydrogenase; Catalyzes the dehydration of galactarate to form 5-dehydro-4- deoxy-D-glucarate.
 
 
 0.996
garL
2-dehydro-3-deoxy-galactarate Aldolase; Catalyzes the reversible retro-aldol cleavage of both 5-keto- 4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde; Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.
  
 
 0.989
gudT
Putative MFS superfamily D-glucarate permease; Similar to E. coli putative transport protein (AAC75831.1); Blastp hit to AAC75831.1 (450 aa), 96% identity in aa 1 - 450.
 
  
 0.986
STM3697
Putative mandelate racemase; Catalyzes the efficient dehydration of both L-talarate and galactarate to 5-keto-4-deoxy-D-glucarate. Also catalyzes the epimerization of L-talarate to galactarate; epimerization occurs in competition with dehydration. Is required for the utilization of L- talarate as a carbon source. Also functions in galactarate utilization. Is not active on other acid sugars; Belongs to the mandelate racemase/muconate lactonizing enzyme family.
 
  
  0.951
ygcY
Similar to E. coli putative glucarate dehydratase (AAC75830.1); Blastp hit to AAC75830.1 (446 aa), 95% identity in aa 1 - 446.
 
  
0.950
STM2959
Putative glycerate kinase 2; Similar to E. coli orf, hypothetical protein (AAC76158.1); Blastp hit to AAC76158.1 (408 aa), 68% identity in aa 28 - 405; Belongs to the glycerate kinase type-1 family.
  
  
 0.909
garR
Tartronate semialdehyde reductase (TSAR); Catalyzes the reduction of tatronate semialdehyde to D- glycerate; Belongs to the HIBADH-related family. 2-hydroxy-3- oxopropionate reductase subfamily.
  
 0.894
garK
Glycerate kinase; Similar to E. coli orf, hypothetical protein (AAC76158.1); Blastp hit to AAC76158.1 (408 aa), 86% identity in aa 28 - 408; Belongs to the glycerate kinase type-1 family.
  
  
 0.805
corE
Putative cytochrome c-type biogenesis protein; Heme exporter protein C; CorE (gi|4877800).
      
 0.740
ycjX
Similar to E. coli putative EC 2.1 enzymes (AAC74403.1); Blastp hit to AAC74403.1 (465 aa), 93% identity in aa 1 - 465.
      
 0.708
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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