STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ygdHPutative nucleotide binding; Similar to E. coli orf, hypothetical protein (AAC75837.1); Blastp hit to AAC75837.1 (454 aa), 94% identity in aa 1 - 453. (454 aa)    
Predicted Functional Partners:
yrfG
Similar to E. coli putative phosphatase (AAC76424.1); Blastp hit to AAC76424.1 (237 aa), 85% identity in aa 16 - 237.
 
  
  0.916
STM3334
Similar to E. coli cytosine deaminase (AAC73440.1); Blastp hit to AAC73440.1 (427 aa), 83% identity in aa 1 - 427.
    
  0.912
amn
AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.
   
 
 0.911
surE
Survival protein, protein damage control; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
    
  0.908
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
    
 0.907
purB
Similar to E. coli adenylosuccinate lyase (AAC74215.1); Blastp hit to AAC74215.1 (456 aa), 94% identity in aa 1 - 456.
  
 
  0.907
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
    
  0.905
icc
Cyclic 3',5'-adenosine monophosphate phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
  
 
  0.905
udk
Similar to E. coli uridine/cytidine kinase (AAC75127.1); Blastp hit to AAC75127.1 (231 aa), 95% identity in aa 19 - 231.
    
  0.901
yjjG
Putative haloacid dehalogenase-like hydrolase; Similar to E. coli putative phosphatase (AAC77327.1); Blastp hit to AAC77327.1 (225 aa), 91% identity in aa 1 - 225.
    
  0.901
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.