STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppdCPrepilin peptidase dependent protein C; Putative component in type IV pilin biogenesis; similar to E. coli prepilin peptidase dependent protein C (AAC75862.1); Blastp hit to AAC75862.1 (107 aa), 69% identity in aa 1 - 106. (106 aa)    
Predicted Functional Partners:
ygdB
Putative periplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75863.1); Blastp hit to AAC75863.1 (121 aa), 52% identity in aa 1 - 121.
  
  
 0.974
ppdB
Prepilin peptidase dependent protein B; Putative component in type IV pilin biogenesis; similar to E. coli prepilin peptidase dependent protein B (AAC75864.1); Blastp hit to AAC75864.1 (187 aa), 67% identity in aa 3 - 187.
  
  
 0.973
ppdA
Prepilin peptidase dependent protein A; Putative component in type IV pilin biogenesis; similar to E. coli prepilin peptidase dependent protein A (AAC75865.1); Blastp hit to AAC75865.1 (156 aa), 65% identity in aa 1 - 155.
  
  
 0.968
hofB
Putative integral membrane protein; Involved in biogenesis of fimbriae (type IV pilin), protein transport, DNA uptake; similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73218.1); Blastp hit to AAC73218.1 (461 aa), 69% identity in aa 1 - 459.
  
  
 0.925
hofC
Similar to E. coli putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake (AAC73217.1); Blastp hit to AAC73217.1 (400 aa), 67% identity in aa 1 - 400.
  
  
 0.899
ppdD
Prelipin peptidase dependent protein; Putative major component of type IV pilin; similar to E. coli prelipin peptidase dependent protein (AAC73219.1); Blastp hit to AAC73219.1 (146 aa), 89% identity in aa 1 - 146.
   
  
 0.885
recC
Exonuclease V, subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzy [...]
     
 0.849
hofQ
Putative transport protein; Possibly in biosynthesis of type IV pilin; similar to E. coli putative transport portein (AAC76416.1); Blastp hit to AAC76416.1 (412 aa), 86% identity in aa 1 - 412.
     
 0.759
guaC
GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
      
 0.672
thyA
Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
  
 0.620
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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