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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vapCPutative nucleic acid-binding protein; Toxic component of a type II toxin-antitoxin (TA) system. A site-specific tRNA-(fMet) endonuclease, it cleaves both charged and uncharged tRNA-(fMet) between positions 38 and 39 at the anticodon stem-loop boundary. Does not cleave tRNA(Met), tRNA(Arg2), tRNA(His), tRNA(Leu), tRNA(Phe) tRNA(Thr1), tRNA(Tyr) or tRNA(Val). Overexpression in E.coli inhibits translation, leads to loss of cell growth and degradation of tRNA(fMet), these effects are neutralized by expression of cognate antitoxin VapB. Expression also activates translation initiation at c [...] (132 aa)    
Predicted Functional Partners:
vapB
Putative cytoplasmic protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin VapC.
 
 
 0.999
yhhV
Putative cytoplasmic protein; Putative antitoxin component of a toxin-antitoxin (TA) system; its cognate toxin is unknown.
     
 0.870
abrB
Similar to E. coli putative transport protein (AAC73809.1); Blastp hit to AAC73809.1 (363 aa), 80% identity in aa 16 - 361.
      
 0.837
parE
DNA topoisomerase IV, subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. Belongs to the type II topoisomerase family. ParE type 1 subfamily.
      
 0.753
STM4030
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76117.1); Blastp hit to AAC76117.1 (138 aa), 45% identity in aa 19 - 138.
  
     0.733
putA
Plasma membrane proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
   
   0.678
STM4528
Putative inner membrane protein.
  
   
 0.678
STM4529
Putative cytoplasmic protein.
  
     0.633
STM4031
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC76118.1); Blastp hit to AAC76118.1 (104 aa), 40% identity in aa 1 - 99.
  
     0.609
STM4450
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC74636.1); Blastp hit to AAC74636.1 (95 aa), 67% identity in aa 1 - 94.
 
   
 0.586
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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