Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
yqgCPutative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75977.1); Blastp hit to AAC75977.1 (71 aa), 78% identity in aa 1 - 51. (54 aa)    
Predicted Functional Partners:
yadG
Putative ABC-type multidrug transport system, ATPase component; Similar to E. coli putative ATP-binding component of a transport system (AAC73238.1); Blastp hit to AAC73238.1 (308 aa), 95% identity in aa 1 - 308.
      
 0.896
nrdB
Ribonucleoside-diphosphate reductase 1, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis; Belongs to the ribonucleoside diphosphate reductase small chain family.
      
 0.740
topA
DNA topoisomerase type I, omega protein; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, th [...]
      
 0.579
speA
Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine.
       0.537
yqgB
Putative inner membrane protein; Similar to E. coli orf, hypothetical protein (AAC75976.1); Blastp hit to AAC75976.1 (48 aa), 73% identity in aa 6 - 46.
       0.537
rfaL
O-antigen ligase; Adds the O-antigen on the glucose(II) group of LPS.
      
 0.451
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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