STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
galPMFS family galactose:proton symporter; Similar to E. coli galactose-proton symport of transport system (AAC75980.1); Blastp hit to AAC75980.1 (464 aa), 97% identity in aa 1 - 464; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (464 aa)    
Predicted Functional Partners:
glk
Glucokinase; Similar to E. coli glucokinase (AAC75447.1); Blastp hit to AAC75447.1 (321 aa), 93% identity in aa 1 - 321; Belongs to the bacterial glucokinase family.
 
  
 0.758
crr
Glucose-specific IIA component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. It can also phosphorylate mannose, methyl alpha-glucoside and 2-deoxy-glucose. The non-phosphorylated EIII-Glc is an inhibitor for uptake of certain sugars such as maltose, melibiose, lactose, and glycerol. Phosphorylated EIII-Glc [...]
      
 0.698
STM0719
Similar to E. coli UDP-galactopyranose mutase (AAC75097.1); Blastp hit to AAC75097.1 (367 aa), 39% identity in aa 5 - 366.
      
 0.680
ptsG
Glucose-specific IIBC component of the Sugar Specific PTS family; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. Also functions as a chemoreceptor monitoring the environment for changes in sugar concentration. It can also phosphorylate mannose, methyl alpha-glucoside and 2-deoxy-glucose.
      
 0.676
ptsH
Phosphohistidinoprotein-hexose phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
      
 0.675
galR
Transcriptional repressor of galETK operon; Repressor of the galactose operon. Binds galactose as an inducer (By similarity).
      
 0.672
galT
Galactose-1-phosphate uridylyltransferase. (SW:GAL7_SALTY).
      
 0.606
sprT
Putative cytoplasmic protein; Similar to E. coli orf, hypothetical protein (AAC75981.1); Blastp hit to AAC75981.1 (165 aa), 90% identity in aa 1 - 164; Belongs to the SprT family.
       0.605
galM
Galactose-1-epimerase (mutarotase); Converts alpha-aldose to the beta-anomer.
   
  
 0.538
endA
Similar to E. coli DNA-specific endonuclease I (AAC75982.1); Blastp hit to AAC75982.1 (235 aa), 87% identity in aa 1 - 235.
       0.486
Your Current Organism:
Salmonella enterica Typhimurium
NCBI taxonomy Id: 99287
Other names: S. enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium LT2, Salmonella enterica subsp. enterica serovar Typhimurium str. LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2, Salmonella enterica subsp. enterica serovar Typhimurium strain LT2-LTL2, Salmonella typhimurium LT2
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